Next Article in Journal
Modeling and Analysis of a Reconfigurable Rover for Improved Traversing over Soft Sloped Terrains
Next Article in Special Issue
A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study
Previous Article in Journal
Comparative Analysis of Mechanical Properties and Microbiological Resistance of Polyfilament and Monofilament Suture Materials Used in the Operation “Tooth Extraction”
Previous Article in Special Issue
Comparison of NIH 3T3 Cellular Adhesion on Fibrous Scaffolds Constructed from Natural and Synthetic Polymers
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomimetics
Volume 8
Issue 1
10.3390/biomimetics8010130
biomimetics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration

by
Rikako Hama
1,2,
James W. Reinhardt
1,
Anudari Ulziibayar
1,
Tatsuya Watanabe
1,
John Kelly
1 and
Toshiharu Shinoka
1,3,4,*
1
Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA
2
Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-Cho, Koganei 184-8588, Japan
3
Department of Cardiothoracic Surgery, The Heart Center, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA
4
Department of Surgery, Cardiovascular Tissue Engineering Program, Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Biomimetics 2023, 8(1), 130; https://doi.org/10.3390/biomimetics8010130
Submission received: 23 February 2023 / Revised: 20 March 2023 / Accepted: 21 March 2023 / Published: 22 March 2023
(This article belongs to the Special Issue Biomimetic Platform for Tissue Regeneration 2.0)
Browse Figures
Review Reports Versions Notes

Abstract

Inducing tissue regeneration in many skin defects, such as large traumatic wounds, burns, other physicochemical wounds, bedsores, and chronic diabetic ulcers, has become an important clinical issue in recent years. Cultured cell sheets and scaffolds containing growth factors are already in use but have yet to restore normal skin tissue structure and function. Many tissue engineering materials that focus on the regeneration process of living tissues have been developed for the more versatile and rapid initiation of treatment. Since the discovery that cells recognize the chemical–physical properties of their surrounding environment, there has been a great deal of work on mimicking the composition of the extracellular matrix (ECM) and its three-dimensional network structure. Approaches have used ECM constituent proteins as well as morphological processing methods, such as fiber sheets, sponges, and meshes. This review summarizes material design strategies in tissue engineering fields, ranging from the morphology of existing dressings and ECM structures to cellular-level microstructure mimicry, and explores directions for future approaches to precision skin tissue regeneration.
Keywords: skin regeneration; dressing materials; tissue engineering; electrospinning nanofiber; sponge; hydrogel; surface topology; mechanobiology skin regeneration; dressing materials; tissue engineering; electrospinning nanofiber; sponge; hydrogel; surface topology; mechanobiology
Graphical Abstract

Share and Cite

MDPI and ACS Style

Hama, R.; Reinhardt, J.W.; Ulziibayar, A.; Watanabe, T.; Kelly, J.; Shinoka, T. Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration. Biomimetics 2023, 8, 130. https://doi.org/10.3390/biomimetics8010130

AMA Style

Hama R, Reinhardt JW, Ulziibayar A, Watanabe T, Kelly J, Shinoka T. Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration. Biomimetics. 2023; 8(1):130. https://doi.org/10.3390/biomimetics8010130

Chicago/Turabian Style

Hama, Rikako, James W. Reinhardt, Anudari Ulziibayar, Tatsuya Watanabe, John Kelly, and Toshiharu Shinoka. 2023. "Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration" Biomimetics 8, no. 1: 130. https://doi.org/10.3390/biomimetics8010130

APA Style

Hama, R., Reinhardt, J. W., Ulziibayar, A., Watanabe, T., Kelly, J., & Shinoka, T. (2023). Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration. Biomimetics, 8(1), 130. https://doi.org/10.3390/biomimetics8010130

Article Metrics

Back to TopTop