Next Article in Journal
Pharmacognostical examination concerning the hemostyptic effect of Achillea millefolium Aggregat
Previous Article in Journal
Synthesis and antimicrobial evaluation of 3-hydrazino-quinoxaline derivatives and their cyclic analoaues
 
 
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Ion-pair Spectrophotometric Determination of Dibucaine

by
Raqi M. Shubietah
1,*,
Ali Z.Abu Zuhri
2 and
Bashar A. Khalid
2
1
Faculty of Pharmacy, An-Najah National University, P.O.Box 7, Nablus, Palestine, via Israel
2
Department of Postgraduate Studies, An-Najah National University, P.O.Box 7, Nablus, Palestine, via Israel
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(2), 189-200; https://doi.org/10.3797/scipharm.aut-00-17
Submission received: 12 December 1999 / Revised: 4 May 2000 / Accepted: 4 May 2000 / Published: 12 May 2000

Abstract

A simple and sensitive spectrophotometric determination of dibucain has been established. It is based on the formation of colored ion-pair complexes between Dibucaine and each of Orange II, Orange G, Bromothymol blue and Bromocresol green. The extract with each of the previous dyes in chloroform exhibited a specific wavelength of maximum absorbance, and all these wavelengths lied in the range 416 to 500 nm. The linear range extended from 1.5 to 60 ppm. The optimum conditions were selected after studying many variables such as pH, shaking time, temperature and dye concentrations. The method was also selective for the analyte and the drug excipients did not interfere.
Keywords: Dibucaine; Ion-pair spectrometry Dibucaine; Ion-pair spectrometry

Share and Cite

MDPI and ACS Style

Shubietah, R.M.; Zuhri, A.Z.A.; Khalid, B.A. Ion-pair Spectrophotometric Determination of Dibucaine. Sci. Pharm. 2000, 68, 189-200. https://doi.org/10.3797/scipharm.aut-00-17

AMA Style

Shubietah RM, Zuhri AZA, Khalid BA. Ion-pair Spectrophotometric Determination of Dibucaine. Scientia Pharmaceutica. 2000; 68(2):189-200. https://doi.org/10.3797/scipharm.aut-00-17

Chicago/Turabian Style

Shubietah, Raqi M., Ali Z.Abu Zuhri, and Bashar A. Khalid. 2000. "Ion-pair Spectrophotometric Determination of Dibucaine" Scientia Pharmaceutica 68, no. 2: 189-200. https://doi.org/10.3797/scipharm.aut-00-17

Article Metrics

Back to TopTop