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Article

Synthesis of Dioxigenated Systems. Preparation of Homologues of 1,4-Benzodioxin as Calcium Antagonists

by
I. Sánchez
1,
M. D. Pujol
1,*,
G. Guillaument
2,
R. Massingham
3 and
A. Monteil
4
1
Laboratori de Química Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain
2
Institut de Chimie Organique et Analytique associé au CNRS, Université d'orleans, BP-6957, 45067 Orleans, cedex 2, France
3
UCB Pharma, Pharmaceutical Sector, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium
4
Laboratoire RL-CERM, La Varenne, rue H. Goudier, 63203 Riom, cedex, France
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2001, 69(1), 11-19; https://doi.org/10.3797/scipharm.aut-01-02
Submission received: 28 December 2000 / Accepted: 6 February 2001 / Published: 30 March 2001
Versions Notes

Abstract

A new compound (9), homologue of 1,4-benzodioxin, has been prepared and tested as calcium antagonist. Additionally, the intermediates 12 and 13 with structure of aminodiol, were also evaluated as anticalcium agents. All of them showed a moderate anticalcium activity.
Keywords: 2,3-dihydro-1,4-benzodioxin; 1,4-benzodioxepin; 1,4-benzodioxocin; anticalcium agents 2,3-dihydro-1,4-benzodioxin; 1,4-benzodioxepin; 1,4-benzodioxocin; anticalcium agents

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MDPI and ACS Style

Sánchez, I.; Pujol, M.D.; Guillaument, G.; Massingham, R.; Monteil, A. Synthesis of Dioxigenated Systems. Preparation of Homologues of 1,4-Benzodioxin as Calcium Antagonists. Sci. Pharm. 2001, 69, 11-19. https://doi.org/10.3797/scipharm.aut-01-02

AMA Style

Sánchez I, Pujol MD, Guillaument G, Massingham R, Monteil A. Synthesis of Dioxigenated Systems. Preparation of Homologues of 1,4-Benzodioxin as Calcium Antagonists. Scientia Pharmaceutica. 2001; 69(1):11-19. https://doi.org/10.3797/scipharm.aut-01-02

Chicago/Turabian Style

Sánchez, I., M. D. Pujol, G. Guillaument, R. Massingham, and A. Monteil. 2001. "Synthesis of Dioxigenated Systems. Preparation of Homologues of 1,4-Benzodioxin as Calcium Antagonists" Scientia Pharmaceutica 69, no. 1: 11-19. https://doi.org/10.3797/scipharm.aut-01-02

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