SYTHESIS AND ANTIBACTERIAL PROPERTIES OF PYRIMIDOPYRIMIDINES
1
Department of Organic Chemistry, Medical Academy. Grodzka 9, 50- 137 Wroclaw, Poland
2
Department of Applied Pharmacy, Medical Academy, Szewska 38,50-137 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2002, 70(3), 245-252; https://doi.org/10.3797/scipharm.aut-02-23
Submission received: 28 January 2002
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Revised: 10 April 2002
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Accepted: 10 April 2002
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Published: 10 July 2002
Simple Summary
The paper presents the synthesis of newly prepared derivatives of 6- methyl-2-phenyl-4-phenylamino-5-aminomethylpyrimidine and 5-methyl- 1,7- diphenyl-l,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine and also the results of microbiological studies. Pyrimidopyrimidine derivatives prepared show a certain analogy in their chemical structure to quinolone structures and also- as it might have been expected - they inhibit to a large extent the growth of bacterial strains, in some cases better than some antibiotics and sulfonamides used at present.
Excerpt
Note: In lieu of an abstract, this is an excerpt from the first page.
Our earlier works on synthesis and biological properties of the pyrimidine ring indicated that this system is extremely biologically active [...]
Keywords:
Pyrimidine, antibacterial action
