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Sci. Pharm.
Volume 76
Issue 2
10.3797/scipharm.0803-14
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Article

Preservative Evaluation of Novel 2,4-Hexadienoic Acid Derivatives in Aluminium Hydroxide Gel – USP

by
Vikramjeet JUDGE
1,
Balasubramanian NARASIMHAN
1,*,
Rakesh NARANG
1,
Ruchita OHLAN
2 and
Sucheta OHLAN
2
1
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125 001, Haryana
2
Hindu College of Pharmacy, Sonepat-131001, Haryana
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2008, 76(2), 269-278; https://doi.org/10.3797/scipharm.0803-14
Submission received: 18 March 2008 / Accepted: 6 May 2008 / Published: 22 May 2008
Versions Notes

Abstract

The potential derivatives of sorbic acid (2,4-hexadienoic acid) from our previous study were subjected to preservative efficacy testing. Aluminium Hydroxide Gel – USP was used as a pharmaceutical product and Staphylococcus aureus MTCC 2901, Bacillus subtilis MTCC 2063, Escherichia coli MTCC 1652, Candida albicans MTCC 227 and Aspergillus niger MTCC 8189 were used as representative challenging microorganisms for antimicrobial effectiveness testing as per USP 2004. The hexadienoic acid derivative, m-nitrosorbanilide has better preservative efficacy than sorbic acid as well as the standard preservatives, methyl paraben and propyl paraben.
Keywords: Sorbic acid; m-Nitrosorbanilide; 8-Quinolinyl sorbate; Preservative; Log CFU/mL Sorbic acid; m-Nitrosorbanilide; 8-Quinolinyl sorbate; Preservative; Log CFU/mL

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MDPI and ACS Style

JUDGE, V.; NARASIMHAN, B.; NARANG, R.; OHLAN, R.; OHLAN, S. Preservative Evaluation of Novel 2,4-Hexadienoic Acid Derivatives in Aluminium Hydroxide Gel – USP. Sci. Pharm. 2008, 76, 269-278. https://doi.org/10.3797/scipharm.0803-14

AMA Style

JUDGE V, NARASIMHAN B, NARANG R, OHLAN R, OHLAN S. Preservative Evaluation of Novel 2,4-Hexadienoic Acid Derivatives in Aluminium Hydroxide Gel – USP. Scientia Pharmaceutica. 2008; 76(2):269-278. https://doi.org/10.3797/scipharm.0803-14

Chicago/Turabian Style

JUDGE, Vikramjeet, Balasubramanian NARASIMHAN, Rakesh NARANG, Ruchita OHLAN, and Sucheta OHLAN. 2008. "Preservative Evaluation of Novel 2,4-Hexadienoic Acid Derivatives in Aluminium Hydroxide Gel – USP" Scientia Pharmaceutica 76, no. 2: 269-278. https://doi.org/10.3797/scipharm.0803-14

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