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Volume 77
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Article

Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach

by
Vivek K. VYAS
1,*,
Anurekha JAIN
2,
Suresh C. MAHAJAN
1,
Radheshyam PATIDAR
1,
Sunil MISTRY
1 and
Subhash C. CHATURVEDI
3
1
Mahakal Institute of Pharmaceutical Studies, Rajiv Gandhi Technical University Behind Air Strip Datana Deaws Road Ujjain 456664 (M.P.) India
2
B. R. Nahata College of Pharmacy, Department of Medicinal Chemistry, Rajiv Gandhi Technical University, Mhow-Neemuch Road 458001 Mandsaur (M.P.) India
3
School of Pharmacy Devi Ahilya Vishwavidylaya, Takshashila Parisar Khandwa road, 452003 Indore (M.P.) India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(1), 33-46; https://doi.org/10.3797/scipharm.0810-01
Submission received: 10 October 2008 / Accepted: 13 January 2009 / Published: 14 January 2009
Versions Notes

Abstract

In the current study a quantitative structure activity relationship approach using sequential multiple linear regression analysis was applied to a series of 2-alkyl- 4-(biphenylylmethoxy)quinolines as angiotensin II (Ang II) receptor antagonists by using Chem 3D and Dragon Software. The studies, carried out on 33 analogs, give statistically significant correlations of selective Ang II antagonistic activity with physical properties concerning size, symmetry, shape and distribution of molecule atoms. Among several 2D quantitative structure activity relationship models, one model gave good statistical significance (r > 0.81, Ftest = 10.47, S < 0.30, chance correlation < 0.01). 3D QSAR studies show that Hennery’s law constant, Dipole and VDWE play a significant role in Ang II antagonistic activity. These QSAR studies help us in the design and prediction of novel substituted benzimidazole Ang II receptor antagonists.
Keywords: QSAR; Angiotensin II antagonists; Hypertension; AT1 and AT2 receptor QSAR; Angiotensin II antagonists; Hypertension; AT1 and AT2 receptor

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MDPI and ACS Style

VYAS, V.K.; JAIN, A.; MAHAJAN, S.C.; PATIDAR, R.; MISTRY, S.; CHATURVEDI, S.C. Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach. Sci. Pharm. 2009, 77, 33-46. https://doi.org/10.3797/scipharm.0810-01

AMA Style

VYAS VK, JAIN A, MAHAJAN SC, PATIDAR R, MISTRY S, CHATURVEDI SC. Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach. Scientia Pharmaceutica. 2009; 77(1):33-46. https://doi.org/10.3797/scipharm.0810-01

Chicago/Turabian Style

VYAS, Vivek K., Anurekha JAIN, Suresh C. MAHAJAN, Radheshyam PATIDAR, Sunil MISTRY, and Subhash C. CHATURVEDI. 2009. "Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach" Scientia Pharmaceutica 77, no. 1: 33-46. https://doi.org/10.3797/scipharm.0810-01

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