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Volume 77
Issue 1
10.3797/scipharm.0812-12
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Article

Isolation and Characterization of an Impurity Obtained During the Synthesis of the Antibiotic Drug Sparfloxacin

by
Nirmala MUNIGELA
1,*,
Moses BABU J.
1,
Anjaneyulu YERRAMILLI
3,
Peddy VISHWESHWAR
1,
Ganesh YADDANAPUDI SESHA SIVA YADDANAPUDI SESHA SIVA
2 and
Narayana Murthy VALAVALA
2
1
Department of Analytical Research, Discovery Research, Dr. Reddy’s Laboratories, Miyapur, Hyderabad 500 049, India
2
Process R&D, Custom pharmaceutical synthesis-II, Dr. Reddy’s Laboratories Ltd., Jeedimetla, Hyderabad, India
3
Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500072, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(1), 67-78; https://doi.org/10.3797/scipharm.0812-12
Submission received: 31 December 2008 / Accepted: 4 February 2009 / Published: 5 February 2009
Versions Notes

Abstract

During the synthesis of Sparfloxacin, a fluoroquinolone antibiotic drug, an unknown impurity (SF5-IMP) was identified in the fifth stage of the synthetic process. The impurity has been isolated from the mother liquor of intermediate SF5. The mother liquor was concentrated to dryness added dichloromethane and stirred for 1 h and filtered to generate SF5-IMP and the molecular structure was elucidated as 7-amino-1-cyclopropyl-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline- 3-carboxylic acid by 19F NMR and single crystal X-ray diffraction studies. The structural features of SF5-IMP and SF5 have been discussed here.
Keywords: Sparfloxacin; 1H NMR; 19F NMR; Single crystal X-ray diffraction Sparfloxacin; 1H NMR; 19F NMR; Single crystal X-ray diffraction

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MDPI and ACS Style

MUNIGELA, N.; BABU J., M.; YERRAMILLI, A.; VISHWESHWAR, P.; YADDANAPUDI SESHA SIVA, G.Y.S.S.; VALAVALA, N.M. Isolation and Characterization of an Impurity Obtained During the Synthesis of the Antibiotic Drug Sparfloxacin. Sci. Pharm. 2009, 77, 67-78. https://doi.org/10.3797/scipharm.0812-12

AMA Style

MUNIGELA N, BABU J. M, YERRAMILLI A, VISHWESHWAR P, YADDANAPUDI SESHA SIVA GYSS, VALAVALA NM. Isolation and Characterization of an Impurity Obtained During the Synthesis of the Antibiotic Drug Sparfloxacin. Scientia Pharmaceutica. 2009; 77(1):67-78. https://doi.org/10.3797/scipharm.0812-12

Chicago/Turabian Style

MUNIGELA, Nirmala, Moses BABU J., Anjaneyulu YERRAMILLI, Peddy VISHWESHWAR, Ganesh YADDANAPUDI SESHA SIVA YADDANAPUDI SESHA SIVA, and Narayana Murthy VALAVALA. 2009. "Isolation and Characterization of an Impurity Obtained During the Synthesis of the Antibiotic Drug Sparfloxacin" Scientia Pharmaceutica 77, no. 1: 67-78. https://doi.org/10.3797/scipharm.0812-12

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