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Volume 77
Issue 2
10.3797/scipharm.0806-08
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Article

Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel

by
Afrouz YOUSEFI
1,2,
Farnaz ESMAEILI
1,2,
Sima RAHIMIAN
2,
Fatemeh ATYABI
1 and
Rassoul DINARVAND
1,3,*
1
Novel Drug Delivery Systems Lab., Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, PO Box 14155-6451, Iran
2
Research and Development Dept., Sobhan Oncology Company, Rasht, Iran
3
Medical Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(2), 453-464; https://doi.org/10.3797/scipharm.0806-08
Submission received: 9 June 2008 / Accepted: 18 March 2009 / Published: 19 March 2009
Versions Notes

Abstract

An improved pegylated liposomal formulation of docetaxel has been developed with the purpose of improving the docetaxel solubility without any need to use tween80 that is responsible for hypersensitivities following administration. Liposomes all had spherical shape with size of 130–160 nm. The most important finding of this study is that pegylated liposomes were prepared with significant increase in docetaxel encapsulation efficiency and stability of the formulation in comparison with last reports on docetaxel liposomes. In vitro release studies revealed that such a formulation could be stable in the blood circulation and meet the requirements for an effective drug delivery system.
Keywords: Docetaxel; Liposome; Stability; Pegylated; Nanoparticle Docetaxel; Liposome; Stability; Pegylated; Nanoparticle

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MDPI and ACS Style

YOUSEFI, A.; ESMAEILI, F.; RAHIMIAN, S.; ATYABI, F.; DINARVAND, R. Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel. Sci. Pharm. 2009, 77, 453-464. https://doi.org/10.3797/scipharm.0806-08

AMA Style

YOUSEFI A, ESMAEILI F, RAHIMIAN S, ATYABI F, DINARVAND R. Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel. Scientia Pharmaceutica. 2009; 77(2):453-464. https://doi.org/10.3797/scipharm.0806-08

Chicago/Turabian Style

YOUSEFI, Afrouz, Farnaz ESMAEILI, Sima RAHIMIAN, Fatemeh ATYABI, and Rassoul DINARVAND. 2009. "Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel" Scientia Pharmaceutica 77, no. 2: 453-464. https://doi.org/10.3797/scipharm.0806-08

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