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Sci. Pharm.
Volume 77
Issue 6
10.3797/scipharm.oephg.21.SL-24
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Abstract

Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging

by
G. RATZINGER
1,*,
P. AGRAWAL
2,
M. WIRTH
1,
W. KÖRNER
3,
K. NICOLAY
2 and
F. GABOR
1
1
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
2
Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands
3
Department of Environmental Geosciences, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(6), 191; https://doi.org/10.3797/scipharm.oephg.21.SL-24
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

To date, the main two classes of clinically used contrast agents for magnetic resonance imaging (MRI) are soluble paramagnetic gadolinium chelates and superparamagnetic iron oxide particles. While iron oxides predominantly increase T2-relaxivity and thus provide negative contrast, gadolinium chelates are often requested as they increase T1-relaxivity and enhance positive contrast. As particulate contrast agents are preferable due to a more favorable signal-to-noise ratio, the goal of our present work was the development of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles labeled with chelated gadolinium.

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MDPI and ACS Style

RATZINGER, G.; AGRAWAL, P.; WIRTH, M.; KÖRNER, W.; NICOLAY, K.; GABOR, F. Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging. Sci. Pharm. 2009, 77, 191. https://doi.org/10.3797/scipharm.oephg.21.SL-24

AMA Style

RATZINGER G, AGRAWAL P, WIRTH M, KÖRNER W, NICOLAY K, GABOR F. Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):191. https://doi.org/10.3797/scipharm.oephg.21.SL-24

Chicago/Turabian Style

RATZINGER, G., P. AGRAWAL, M. WIRTH, W. KÖRNER, K. NICOLAY, and F. GABOR. 2009. "Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging" Scientia Pharmaceutica 77, Short Lectures (SL): 191. https://doi.org/10.3797/scipharm.oephg.21.SL-24

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