Antimicrobial and Antimutagenic Properties of Newly Synthesized Derivatives of Indolizine

Microbial diseases still pose a threat for the population as a consequence of increasing number of microbial strains resistant to antibiotics and chemo-therapeutics of common use. Their treatment remains an important and challenging worldwide problem. There is real perceived need for the discovery of new compounds endowed with antimicrobial activity, possibly acting though mechanisms of action, which are distinct from those of well-known classes of antibacterial agents to which many clinically relevant pathogens are now resistant. Indolizines, the nitrogen containing heterocyclic systems, have been widely distributed in nature.[....]