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Volume 79
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10.3797/scipharm.1003-03
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Article

Optimization, Characterisation and Pharmacokinetic Studies of Mucoadhesive Oral Multiple Unit Systems of Ornidazole

by
Govind S. ASANE
1,*,
Yamsani Madhusudan RAO
2,
Jaykrishna H. BHATT
1 and
Karimunnisa S. SHAIKH
3
1
Department of Pharmaceutics, Pravara Rural College of Pharmacy, Loni- 413736, India
2
University College of Pharmaceutical Sciences, Kakatiya University, Warangal- 506 009, India
3
Department of Pharmaceutics, Poona College of Pharmacy, Pune-411038, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(1), 181-196; https://doi.org/10.3797/scipharm.1003-03
Submission received: 6 March 2010 / Accepted: 29 November 2010 / Published: 2 December 2010
Versions Notes

Abstract

The objective of the present study was to investigate the applicability of matrix type mucoadhesive oral multiple unit systems (MUS) for sustaining the release of ornidazole in the gastrointestinal tract (GIT).The MUS were prepared by ionotropic gelation method using chitosan and hydroxypropyl methyl cellulose K4M (HPMC K4M) according to 32 factorial designs and were evaluated in vitro and in vivo. The particle size length ranged from 0.78 to 1.30 mm and breadth from 0.76 to 1.30 mm, respectively. The entrapment efficiency was in range of 80 to 96%. The rapid wash-off test was observed faster at intestinal pH 6.8 as compared to acidic pH 1.2. The fluoroscopic study revealed the retention of MUS in GIT for more than 5 hours. The pharmacokinetic parameters Cmax, Tmax, mean residence time (MRT) and area under curve (AUC) of developed MUS were found to be improved significantly (p<0.05) when compared with marketed immediate release tablets each containing 500 mg of drug. This study demonstrates that the MUS could be a good alternative to immediate release tablets to deliver ornidazole and expected to be less irritant to gastric and intestinal mucosa.
Keywords: Bioavailability studies; Gastrointestinal transit; Factorial design; Mucoadhesion Bioavailability studies; Gastrointestinal transit; Factorial design; Mucoadhesion

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MDPI and ACS Style

ASANE, G.S.; Madhusudan RAO, Y.; BHATT, J.H.; SHAIKH, K.S. Optimization, Characterisation and Pharmacokinetic Studies of Mucoadhesive Oral Multiple Unit Systems of Ornidazole. Sci. Pharm. 2011, 79, 181-196. https://doi.org/10.3797/scipharm.1003-03

AMA Style

ASANE GS, Madhusudan RAO Y, BHATT JH, SHAIKH KS. Optimization, Characterisation and Pharmacokinetic Studies of Mucoadhesive Oral Multiple Unit Systems of Ornidazole. Scientia Pharmaceutica. 2011; 79(1):181-196. https://doi.org/10.3797/scipharm.1003-03

Chicago/Turabian Style

ASANE, Govind S., Yamsani Madhusudan RAO, Jaykrishna H. BHATT, and Karimunnisa S. SHAIKH. 2011. "Optimization, Characterisation and Pharmacokinetic Studies of Mucoadhesive Oral Multiple Unit Systems of Ornidazole" Scientia Pharmaceutica 79, no. 1: 181-196. https://doi.org/10.3797/scipharm.1003-03

APA Style

ASANE, G. S., Madhusudan RAO, Y., BHATT, J. H., & SHAIKH, K. S. (2011). Optimization, Characterisation and Pharmacokinetic Studies of Mucoadhesive Oral Multiple Unit Systems of Ornidazole. Scientia Pharmaceutica, 79(1), 181-196. https://doi.org/10.3797/scipharm.1003-03

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