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Volume 79
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Article

Identification of Major Degradation Products of Ketoconazole

by
Rajendra A. MHASKE
1,* and
Shirish SAHASRABUDHE
2
1
Sharon Bio Medicine, 312, C-Wing, BSEL Tech Park, Opp. Vashi Railway Station, Sector 30 (A), Vashi, Navi-Mumbai-400703, India
2
Shri Jagdishprasad Jhabarmal Tiberewala University, J. B. Nagar, Andheri (E), Mumbai–400059, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(4), 817-836; https://doi.org/10.3797/scipharm.1107-18
Submission received: 14 July 2011 / Accepted: 13 October 2011 / Published: 13 October 2011
Versions Notes

Abstract

Analytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed under acid, base and oxidative stress conditions. The degradation study was performed on Inertsil ODS-3V, length 100 X diameter 4.6 mm, particle size 3 μm column using gradient method. These degradants were identified by LC-MS technique.
Keywords: Ketoconazole; Stress degradation; Hydrolysis degradent; Oxidative degradent; LC-MS Ketoconazole; Stress degradation; Hydrolysis degradent; Oxidative degradent; LC-MS

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MDPI and ACS Style

MHASKE, R.A.; SAHASRABUDHE, S. Identification of Major Degradation Products of Ketoconazole. Sci. Pharm. 2011, 79, 817-836. https://doi.org/10.3797/scipharm.1107-18

AMA Style

MHASKE RA, SAHASRABUDHE S. Identification of Major Degradation Products of Ketoconazole. Scientia Pharmaceutica. 2011; 79(4):817-836. https://doi.org/10.3797/scipharm.1107-18

Chicago/Turabian Style

MHASKE, Rajendra A., and Shirish SAHASRABUDHE. 2011. "Identification of Major Degradation Products of Ketoconazole" Scientia Pharmaceutica 79, no. 4: 817-836. https://doi.org/10.3797/scipharm.1107-18

APA Style

MHASKE, R. A., & SAHASRABUDHE, S. (2011). Identification of Major Degradation Products of Ketoconazole. Scientia Pharmaceutica, 79(4), 817-836. https://doi.org/10.3797/scipharm.1107-18

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