Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries
Abstract
:1. Introduction
2. Materials and Methods
2.1. In Vivo Experimental Procedures
2.1.1. Animals
2.1.2. Tooth Replantation
2.2. Tissue Preparation
2.3. Immunohistochemical Procedures
2.4. Cell Counting and Statistical Analysis
3. Results
3.1. Histological Evaluation of the Dental Pulp Healing Process by H&E and AZAN Staining and Nestin Immunohistochemistry
3.2. Analysis of Cell Proliferation in the Pulpal Tissue by Ki-67 Immunohistochemistry
3.3. Assessment of Macrophage Activity in the Dental Pulp by F4/80 and CD206 Immunohistochemistry
3.4. TLR9 Immunoexpression in the Afflicted Dental Pulp
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Quispe-Salcedo, A.; Yamazaki, T.; Ohshima, H. Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries. Biomolecules 2024, 14, 931. https://doi.org/10.3390/biom14080931
Quispe-Salcedo A, Yamazaki T, Ohshima H. Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries. Biomolecules. 2024; 14(8):931. https://doi.org/10.3390/biom14080931
Chicago/Turabian StyleQuispe-Salcedo, Angela, Tomohiko Yamazaki, and Hayato Ohshima. 2024. "Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries" Biomolecules 14, no. 8: 931. https://doi.org/10.3390/biom14080931