Redox Status Response of Physical Exercise Training in Women with Breast Cancer during Trastuzumab Therapy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Study Setting and Participants
2.2.1. BC + PE Group
2.2.2. Usual Physical Activity Group (without Regular Physical Exercises)
2.2.3. Control Group
2.3. Methods
2.3.1. Capacity Test
2.3.2. Doppler Echocardiography
2.3.3. Redox Measurements
Antioxidant Defenses
Redox Status
Oxidative Stress
Nitrosative Stress
2.3.4. Statistical Analysis
3. Results
3.1. Study Participants
3.2. Capacity Test
3.3. The Analysis of Echocardiography Results
3.4. Differences in Antioxidant Enzymes (SOD, CAT, and GSH-Px) and Non-Enzymatic Antioxidants (GSH) in the Study Groups
3.5. Analysis of Results for Redox Status of Study Groups
3.6. Analysis of Results for Oxidative Stress of Study Groups
3.7. Analysis of Results for Nitrosative Stress Parameters of Study Groups
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameter | CG (N = 50) | BC (N = 25) | BC + PE (N = 25) | p | |
---|---|---|---|---|---|
Age [years] | mean ± SD | 54.64 ± 4.26 | 53.43 ± 3.68 | 52.24 ± 7.29 | 0.78 |
Weight [kg] | mean ± SD | 68.73 ± 7.5 | 63.25 ± 5.53 | 65.69 ± 8.51 | 0.121 |
Height [m] | mean ± SD | 1.68 ± 0.57 | 1.65 ± 0.64 | 1.66 ± 0.24 | 0.234 |
BMI [kg/m2] | mean ± SD | 24.22 ± 2.46 | 25.35 ± 1.89 | 24.35 ± 5.6 | 0.409 |
Medical history N (%) | |||||
Surgical treatment | BCT | 0 | 13 (52%) | 11 (44%) | |
Mastectomy | 0 | 2 (8%) | 3 (12%) | ||
Mastectomy with reconstruction | 0 | 10 (40%) | 11 (44%) | ||
Side of operated breast cancer | Left | 0 | 14 (56%) | 16 (64%) | |
Right | 0 | 11 (44%) | 9 (36%) | ||
Cancer stage | IB | 0 | 1 (4%) | 2 (8%) | |
IIA | 0 | 11 (44%) | 9 (36%) | ||
IIB | 0 | 13 (52%) | 14 (56%) | ||
Previous anthracycline treatment | 0 | 20 (80%) | 22(88%) | ||
Hormonal therapy | 0 | 22 (88%) | 22(88%) | ||
NYHA I | 13(26%) | 9 (36%) | 13 (26%) | ||
NYHA II | 2(4%) | 4 (16%) | 2 (4%) | ||
Another illness bearing a cardiac risk N (%) | |||||
Coronary artery disease | 0 (0%) | 0 (0%) | 0 (0%) | ||
Dyslipidemia | 2 (4%) | 3 (12%) | 4 (16%) | ||
Hypertension | 3 (6%) | 2 (8%) | 5 (20%) | ||
History of smoking | 2 (4%) | 1 (%) | 2 (8%) |
Parameters | CG (N = 50) | BC (N = 25) | BC + PE (N = 25) | p |
---|---|---|---|---|
Mean ± SD | ||||
6MWD [m] | 451.6 ± 55.33 | 441.6 ± 24.88 | 449.7 ± 50.06 | 0.314 |
MET Unit | 3.19 ± 0.26 | 3.11 ± 0.12 | 3.14 ± 0.24 | 0.211 |
Borg scale [point] | 1.29 ± 0.7 | 1.82 ± 0.6 | 1.62 ± 0.72 | 0.698 |
Parameters | CG (N = 50) | BC (N = 25) | BC + PE (N = 25) | p |
---|---|---|---|---|
Mean ± SD | ||||
LVEF [%] | 65.59 ± 5.02 | 63,9 ± 2.52 | 64.46 ± 3.71 | 0.114 |
GLS [%] | 17.4 ± 2.5 | 16.9 ± 2.5 | 16.8 ± 2.5 | 0.271 |
LAVI [mL/m2] | 24.5 ± 2.5 | 23.8 ± 2.5 | 24.2 ± 2.5 | 0.177 |
RVEF [%] | 53.2 ± 4.5 | 52.5 ± 7.1 | 52.2 ± 6.4 | 0.563 |
TAPSE [mm] | 21.1 ± 3.1 | 20.1 ± 3.6 | 20.4 ± 2.7 | 0.662 |
E/A | 1.5 ± 0.5 | 1.4 ± 0.5 | 1.4 ± 0.5 | 0.878 |
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Hojan, K.; Gerreth, K.; Procyk, D.; Mania, K.; Zalewska, A.; Maciejczyk, M. Redox Status Response of Physical Exercise Training in Women with Breast Cancer during Trastuzumab Therapy. Healthcare 2022, 10, 2039. https://doi.org/10.3390/healthcare10102039
Hojan K, Gerreth K, Procyk D, Mania K, Zalewska A, Maciejczyk M. Redox Status Response of Physical Exercise Training in Women with Breast Cancer during Trastuzumab Therapy. Healthcare. 2022; 10(10):2039. https://doi.org/10.3390/healthcare10102039
Chicago/Turabian StyleHojan, Katarzyna, Karolina Gerreth, Danuta Procyk, Krystian Mania, Anna Zalewska, and Mateusz Maciejczyk. 2022. "Redox Status Response of Physical Exercise Training in Women with Breast Cancer during Trastuzumab Therapy" Healthcare 10, no. 10: 2039. https://doi.org/10.3390/healthcare10102039