Application of Artificial Intelligence in Orthodontics: Current State and Future Perspectives

Round 1

Reviewer 1 Report

Dear colleagues, 

congratulations of this very interesting manuscript. 

Please consider these comments for revision:

1.       ll. 23/24:      This sentence is not really comprehensible. Maybe formulate it as: “…, the field of AI has a lot of potential as AI can be employed to solve a variety of tasks.”        

2.       ll. 36-45:      Please describe the most prominent differences between ANN and CNN and why CNN are usually preferred for computer vision and image-dependant machine learning.

3.       Ll. 51/52      This bold statement needs to be underlined by sufficient source.

4.       Ll. 54/55      Please add a source here.

5.       Ll. 57/58      Please add a source here.

6.       Ll. 65             Please add source when you mention other reviews.

7.       Please add a section Material and Methods to describe your search strategy, inclusion and exclusion criteria etc. See: https://www.equator-network.org/reporting-guidelines/prisma/

8.       Ll. 76-80       Please add a source here.

9.       Ll. 84-86       Please add a source here.

10.   Ll. 88-90       Please add a source here.

11.   Ll. 92-83       Please explain in M&M how you selected the literature and how you assessed the quality of each paper

12.   Ll. 100-102  What about homogeneity of the results? Was any statistic test applicable?

13.   Ll. 120/121 Please quickly describe why these processes are drawbacks (time consuming, etc.).

14.   L. 134            Please explain this term to the reader in one short sentence.

15.   L. 141           Maybe also explain the differences in technique between CNN application on radiographs and photos.

16.   Ll. 153/154 Are there any publications on these "automated measurements"? How do they work?

17.   Ll. 163/164  Please describe you search strategy and criteria. You wrote that you concentrated on recent articles...

18.   Ll. 169-171  What are the results of these experiments?

19.   Ll. 179/180  Please add a source here.

20.   L. 181            Please explain this method.

21.   Ll. 190/191  Interesting finding. Is there a hypothesis on why this was the case?

22.   L. 290            Please add a short summary for this paragraph.

23.   Ll. 212/123  Please add a source and explain why upper airway obstruction is important for facial growth and development (one sentence).

24.   Ll. 247/248  Please give a source here.

25.   Ll. 255/256  Please give a source here.

26.   Ll. 269/270  Please give a little more context and background information on these two algorithms.

27.   L. 274            Please explain SVM in a short sentence.

28.   L. 282            Please add a short summary for this paragraph.

29.   Ll. 285/286  Please give a source here.

30.   L. 305            Please add a short summary for this paragraph.

31.   Ll. 308/310 Please give a source here.

32.   Ll. 313/314  Please give a source here.

33.   Ll. 317/319  Please give a source here.

34.   Ll. 331/332  Please give a short explanation of cGAN

35.   L. 342            Please add a short summary for this paragraph.

36.   Ll. 346/347  Please give a source here.

37.   L. 357            Please give a short explanation of 3D-UnetSE

38.   Ll. 371-373  Please give a source here.

39.   L. 397            Please give a short explanation of DeepID

40.   Ll. 415/417  Please give a short explanation for all of these

41.   Ll. 419/420  Please explain Blockchain technology in a short sentence.

42.   Ll. 436-438  Please explain a little

43.   Ll. 445/446  Would that not be a good criteria to judge the quality of the presented papers?

 

I believe, that this review will give a thorough overview of the current state of AI application in orthodontics and will help improve research quality and comparability.

Nonetheless, some revisions are necessary before the final acceptance.

The quality of English is sufficient.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

see attached

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

Paper needs revision for grammar and. Correction of numerous typos in the text

can you add the major findings to the abstract, you can use subheadings 

I suggest you present the paper in systematic approach and define PICO

also you can decide this into 2 papers one based on diagnosis and the other one treatment plan 

line 36-50 , definition of malocclusion is not accurate , correct to Malocclusion is a deviation form norm and manifestation of normal biological variability (Eur J Orthod. 2009 31(5):477-84.)

mention that nearly 30% of any population present with great need for orthodontic treatment (World J Orthod. 2010 ;11(1):43-8) 

section 2.1.2 dental analysis is not written well, revise 

in future prospective suggest programs that detect orthodontic treatment needs like IOTN (Prog Orthod. 2011;12(2):132-42; ) or  IOFTN for orthognathic treatment need indices (J Plast Reconstr Aesthet Surg. 2016 Jun;69(6):796-801)

 

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Paper needs revision

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

Thank you for the revisions, a good contribution to AI in orthodontics 

Minor editing would be beneficial