Development of Clinical Prediction Score for Chemotherapy Response in Advanced Non-Small Cell Lung Cancer Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Outcome
2.3. Predictors
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Responder | Non-Responder | p-Value | ||
---|---|---|---|---|---|
CR + PR (n = 117) | SD + PD (n = 90) | ||||
n | % | n | % | ||
I. Patient factors | |||||
Gender | |||||
Male | 50 | 42.7 | 55 | 61.1 | 0.011 |
Female | 67 | 57.3 | 35 | 38.9 | |
Age (year) * | 62.8 | (±9.6) | 61.4 | (±10.4) | 0.298 |
Smoking status | |||||
Current/ex-smoking | 40 | 34.2 | 33 | 38.8 | 0.554 |
Never | 77 | 65.8 | 52 | 61.2 | |
TNM staging | |||||
II | 1 | 0.9 | 0 | 0.0 | 0.503 |
IIIA | 3 | 2.6 | 2 | 2.2 | |
IIIB | 8 | 6.8 | 4 | 4.4 | |
IV | 105 | 89.7 | 84 | 93.4 | |
PS | |||||
ECOG 0–1 | 102 | 90.3 | 70 | 85.4 | 0.369 |
ECOG ≥ 2 | 11 | 9.7 | 12 | 14.6 | |
Significant weight loss ** | |||||
Yes | 35 | 30.4 | 28 | 31.5 | 0.880 |
No | 80 | 69.6 | 61 | 68.5 | |
BMI (kg/m2) | |||||
<18.5 | 35 | 29.9 | 35 | 38.9 | 0.251 |
18.5–22.9 | 48 | 41.0 | 37 | 41.1 | |
≥23 | 34 | 29.1 | 18 | 20.0 | |
II. Pathological factors | |||||
Histology | |||||
Adenocarcinoma | 72 | 64.3 | 62 | 69.7 | 0.013 |
Squamous cell carcinoma | 37 | 33.0 | 17 | 19.1 | |
Large cell carcinoma | 0 | 0.0 | 1 | 1.1 | |
NOS | 3 | 2.7 | 9 | 10.1 | |
Tumor grading | |||||
Well-differentiated | 5 | 4.3 | 7 | 7.8 | 0.209 |
Moderately differentiated | 5 | 4.3 | 9 | 10.0 | |
Poorly differentiated | 21 | 18.0 | 13 | 14.4 | |
Undifferentiated | 0 | 0.0 | 1 | 1.1 | |
NA | 86 | 73.4 | 60 | 66.7 | |
III. Pre-treatment laboratory results | |||||
Albumin (g/dL) * | 3.5 | (±0.5) | 3.4 | (±0.4) | 0.069 |
Hemoglobin (g/dL) * | 11.4 | (±1.6) | 11.5 | (±2.3) | 0.627 |
WBCs (cells/mm3) * | 9737.3 | (±4549.8) | 9389.8 | (±3112.6) | 0.536 |
ANC (cells/mm3) * | 6617.6 | (±3249.3) | 6613.9 | (±2742.1) | 0.993 |
CEA (ng/mL) *** | 47.9 | (10.9, 258.4) | 42.4 | (10.5, 116.2) | 0.411 |
Parameters | Coefficient | RR | 95% CI of RR | p-Value |
---|---|---|---|---|
Female | 0.56 | 1.75 | 1.20–2.55 | 0.004 |
Age ≥ 60 years | 0.15 | 1.16 | 0.90–1.49 | 0.259 |
Current/ex-smoking | 0.32 | 1.38 | 0.94–2.02 | 0.100 |
ECOG 0–1 | 0.18 | 1.20 | 0.75–1.90 | 0.447 |
Squamous cell carcinoma | 0.35 | 1.41 | 1.10–1.81 | 0.006 |
Albumin ≥ 3.5 mg/dL | 0.33 | 1.40 | 1.06–1.85 | 0.019 |
Clinical Parameters | Coefficient | Transformed Coefficient | Assigned Score |
---|---|---|---|
Gender | |||
Female | 0.56 | 3.83 | 4 |
Male | - | - | 0 |
Age | |||
≥60 years | 0.15 | 1.00 | 1 |
<60 years | - | - | 0 |
Smoking status | |||
Current/ex-smoking | 0.32 | 2.21 | 2 |
Never | - | - | 0 |
ECOG | |||
0–1 | 0.18 | 1.24 | 1 |
2 | - | - | 0 |
Albumin | |||
≥3.5 mg/dL | 0.33 | 2.29 | 2.5 |
<3.5 mg/dL | - | - | 0 |
Histologic subtype | |||
Squamous cell carcinoma | 0.35 | 2.37 | 2.5 |
Non-squamous cell carcinoma | - | - | 0 |
Risk Level | Responder | Non-Responder | PPV (%) | LHR+ | 95% CI of LHR+ | p-Value |
---|---|---|---|---|---|---|
n (%) | n (%) | |||||
Low (0–8) | 65 (50.0) | 65 (50.0) | 50.0 | 0.34 | 0.18–0.66 | <0.001 |
High (8.5–13) | 36 (83.7) | 7 (16.3) | 83.7 | 3.67 | 1.73–7.77 | <0.001 |
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Chayangsu, C.; Khorana, J.; Charoentum, C.; Sriuranpong, V.; Patumanond, J.; Tantraworasin, A. Development of Clinical Prediction Score for Chemotherapy Response in Advanced Non-Small Cell Lung Cancer Patients. Healthcare 2023, 11, 293. https://doi.org/10.3390/healthcare11030293
Chayangsu C, Khorana J, Charoentum C, Sriuranpong V, Patumanond J, Tantraworasin A. Development of Clinical Prediction Score for Chemotherapy Response in Advanced Non-Small Cell Lung Cancer Patients. Healthcare. 2023; 11(3):293. https://doi.org/10.3390/healthcare11030293
Chicago/Turabian StyleChayangsu, Chawalit, Jiraporn Khorana, Chaiyut Charoentum, Virote Sriuranpong, Jayanton Patumanond, and Apichat Tantraworasin. 2023. "Development of Clinical Prediction Score for Chemotherapy Response in Advanced Non-Small Cell Lung Cancer Patients" Healthcare 11, no. 3: 293. https://doi.org/10.3390/healthcare11030293