Exploration of Therapeutic Strategies of Herbal Prescriptions for Carbuncle Treatment to Suggest Modern Approaches to Inflammatory Bowel Disease: Cluster and Network Analyses of the Book «Liu Juan Zi Gui Yi Fang»
Abstract
:1. Introduction
2. Material and Methods
2.1. Selection of Prescriptions for Treating Carbuncles
2.2. Data Extraction, Standardization, and Tokenization
2.3. Prescription Clustering Based on EATM Expert Knowledge
2.4. Hierarchical and Non-Hierarchical Cluster Analysis
2.4.1. Jaccard Index Calculation as a Similarity Measure
2.4.2. Hierarchical Cluster Analysis
2.4.3. k-Means Cluster Analysis
2.5. Construction and Analysis of Heterogeneous Information Network of Herb–Indication (H-I) Relationship
3. Results
3.1. Prescription Clustering by EATM Expert Group
3.2. Results of Hierarchical Cluster Analysis
3.3. Prescription Group Partitioning by k-Means Cluster Analysis
3.4. Sensitivity Analysis of the Impact of the Pre-Specified Number of Clusters on Prescription Clustering by k-Means Cluster Analysis
3.5. Sensitivity Analysis of the Impact of Initial Centroid Position Changes on Prescription Clustering by k-Means Cluster Analysis
3.6. Constructing the Herb–Indication Relationship Network for Carbuncle Treatment Prescriptions
3.7. Cluster-Specific H-I Subnetworks
4. Discussion
4.1. Summary of Findings
4.2. Modern Applications of Herbal Prescriptions for IBD Management in Clinical Practice and Suggestions for Further Research
4.3. Importance of Integrating Expert Insights with Data Mining Methodology in EATM Knowledge Enrichment
4.4. Strengths and Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Common Major Indications * | Common Major Herbs ** | |
---|---|---|
Subset 1 | Diarrhea Coldness Abscess Abscess ruptured | H1 Gan cao, H10 Jie geng, H12 Dan gui, H25 Bai tou weng, H27 Bai shi zhi, H31 Fu zi, H46 Long gu, H49 ren shen, H69 Huang lian |
Subset 2 | The early phase of the disease Difficulty in defecation Difficulty in urination Fever | H1 Gan cao, H12 Dan gui, H15 Da huang, H42 Sheng ma, H67 Huang qin |
Subset 3 | Abscess ruptured Deficiency Fever | H1 Gan cao, H4 Gan di huang, H14 Da zao, H19 Mai dong, H30 Fu ling, H36 Sheng jiang, H49 Ren shen, H68 Huang qi |
Subset 4 | Fever Deficiency Thirst | H1 Gan cao, H12 Dang gui, H30 Fu ling, H37 Sheng di huang, H49 Ren shen, H50 Shao yao, H55 Dan zhu ye, H64 Tong cao, H67 Huang qin, H68 Huang qi |
Subset 5 | After laxation Difficulty in urination Fever | H1 Gan cao, H6 Gui xin, H12 Dang gui, H19 Mai dong, H41 Xiao mai, H49 Ren shen, H50 Shao yao, H55 Dan zhu ye, H67 Huang qin |
Subset 6 | Abscess unruptured Abscess Abscess ruptured | H7 Gua lou, H50 Shao yao, H52 Chi xiao dou, H58 Chuan xiong, H68 Huang qi |
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Park, D.; Jeong, H.; Leem, J. Exploration of Therapeutic Strategies of Herbal Prescriptions for Carbuncle Treatment to Suggest Modern Approaches to Inflammatory Bowel Disease: Cluster and Network Analyses of the Book «Liu Juan Zi Gui Yi Fang». Healthcare 2024, 12, 1499. https://doi.org/10.3390/healthcare12151499
Park D, Jeong H, Leem J. Exploration of Therapeutic Strategies of Herbal Prescriptions for Carbuncle Treatment to Suggest Modern Approaches to Inflammatory Bowel Disease: Cluster and Network Analyses of the Book «Liu Juan Zi Gui Yi Fang». Healthcare. 2024; 12(15):1499. https://doi.org/10.3390/healthcare12151499
Chicago/Turabian StylePark, Dasol, Heonyoung Jeong, and Jungtae Leem. 2024. "Exploration of Therapeutic Strategies of Herbal Prescriptions for Carbuncle Treatment to Suggest Modern Approaches to Inflammatory Bowel Disease: Cluster and Network Analyses of the Book «Liu Juan Zi Gui Yi Fang»" Healthcare 12, no. 15: 1499. https://doi.org/10.3390/healthcare12151499