Mediating Effect of IADL and Depression in the Relationship Between Ability to Perform Movements and Death Preparation in Elderly with Osteoarthritis or Rheumatoid Arthritis
Abstract
:1. Introduction
1.1. Background
1.2. Purpose of This Study
2. Materials and Methods
2.1. Study Design
2.2. Participants
2.3. Study Variables
2.3.1. Ability to Perform Movements
2.3.2. Death Preparation
2.3.3. IADL
2.3.4. Depression
2.4. Ethical Considerations
2.5. Analysis
3. Results
3.1. General Characteristics Based on Death Preparation
3.2. Correlation Between the Ability to Perform Movements, Death Preparation, IADL, and Depression
3.3. Mediating Effect of IADL and Depression on the Relationship Between the Ability to Perform Movements and Death Preparation
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Australian Bureau of Statistics (ABS). Deaths, Australia, 2016; ABS: Canberra, Australia, 2017. [Google Scholar]
- Pinquart, M.; Sörensen, S. Preparation for death and preparation for care in older community-dwelling adults. OMEGA J. Death Dying 2002, 45, 69–88. [Google Scholar] [CrossRef]
- Cai, X.; Yuan, S.; Zeng, Y.; Wang, C.; Yu, N.; Ding, C. New trends in pharmacological treatments for osteoarthritis. Front. Pharmacol. 2021, 12, 645842. [Google Scholar] [CrossRef]
- Kontio, T.; Heliövaara, M.; Viikari-Juntura, E.; Solovieva, S. To what extent is severe osteoarthritis preventable? Occupational and non-occupational risk factors for knee and hip osteoarthritis. Rheumatology 2020, 59, 3869–3877. [Google Scholar] [CrossRef] [PubMed]
- Almutairi, K.; Nossent, J.; Preen, D.; Keen, H.; Inderjeeth, C. The global prevalence of rheumatoid arthritis: A meta-analysis based on a systematic review. Rheumatol. Int. 2021, 41, 863–877. [Google Scholar] [CrossRef] [PubMed]
- Moon, S.; Oh, E.; Chung, D.; Hong, G.R.S. Changes in instrumental activities daily living limitations and their associated factors according to gender in community-residing older adults: A longitudinal cohort study. PLoS ONE 2024, 19, e0296796. [Google Scholar] [CrossRef]
- Holmberg, T.; Davidsen, M.; Thygesen, L.C.; Krøll, M.J.; Tolstrup, J.S. Mortality among persons experiencing musculoskeletal pain: A prospective study among Danish men and women. BMC Musculoskelet. Disord. 2020, 21, 666. [Google Scholar] [CrossRef]
- Beşirli, A.; Alptekin, J.Ö.; Kaymak, D.; Özer, Ö.A. The relationship between anxiety, depression, suicidal ideation and quality of life in patients with rheumatoid arthritis. Psychiatr. Q. 2020, 91, 53–64. [Google Scholar] [CrossRef]
- Shafrin, J.; Sullivan, J.; Goldman, D.P.; Gill, T.M. The association between observed mobility and quality of life in the near elderly. PLoS ONE 2017, 12, e0182920. [Google Scholar] [CrossRef]
- Ribeiro, J.D.; Huang, X.; Fox, K.R.; Franklin, J.C. Depression and hopelessness as risk factors for suicide ideation, attempts and death: Meta-analysis of longitudinal studies. Br. J. Psychiatry 2018, 212, 279–286. [Google Scholar] [CrossRef]
- Akintayo, R.O.; Yerima, A.; Olaosebikan, H.B.; Uhunmwangho, C.; Akpabio, A.A. How much gloom is in groans? Depression and its determinants in Nigerian patients with knee osteoarthritis: A multi-center cross-sectional study. Clin. Rheumatol. 2019, 38, 1971–1978. [Google Scholar] [CrossRef]
- Liu, Y.; van Schalkwyk, G.J. Death preparation of Chinese rural elders. Death Stud. 2019, 43, 270–279. [Google Scholar] [CrossRef]
- Lee, Y.K.; Kim, S.J.; Whang, N.H.; Lim, J.M.; Ju, B.H.; Nam, K.E.; Lee, S.H.; Jeong, K.H.; Kang, E.N.; Kim, K.R. The 2020 Survey on the Elderly; Sejong-si, Republic of Korea, 2020. [Google Scholar]
- Yoon, M.R.; Lee, M.A. The effect of the elderly’s ability to perform daily activities on life satisfaction: Focusing on mediating effect of depression. J. Ind. Converg. 2022, 20, 187–196. [Google Scholar] [CrossRef]
- Won, C.W.; Rho, Y.G.; Sunwoo, D.; Lee, Y.S. The validity and reliability of Korean Instrumental Activities of Daily Living (K-IADL) scale. J. Korean Geriatr. Soc. 2002, 6, 273–280. [Google Scholar]
- Yesavage, J.A.; Brink, T.L.; Rose, T.L.; Lum, O.; Huang, V.; Adey, M.; Leirer, V.O. Development and validation of a geriatric depression screening scale: A preliminary report. J. Psychiatr. Res. 1982, 17, 37–49. [Google Scholar] [CrossRef]
- Kee, B.S. Preliminary study for the standardization of Geriatric Depression Scale Short Form-Korean Version. J. Korean Neuropsychiatr. Assoc. 1996, 35, 298–307. [Google Scholar]
- Hayes, A.F. Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach; The Guilford Press: New York, NY, USA, 2013; p. 692. [Google Scholar]
- Hwang, Y.H.; Jun, H.J.; Park, H.R. Factors influencing intention to use life-sustaining treatment of community-dwelling older adults using the 2020 national survey of older Koreans: Secondary analysis research. J. Korean Gerontol. Nurs. 2022, 24, 424–432. [Google Scholar] [CrossRef]
- Iaboni, A.; Flint, A.J. The complex interplay of depression and falls in older adults: A clinical review. Am. J. Geriatr. Psychiatry 2013, 21, 484–492. [Google Scholar] [CrossRef]
- Chu, L.W.; Chiu, A.Y.Y.; Chi, I. Impact of falls on the balance, gait, and activities of daily living functioning in community-dwelling Chinese older adults. J. Gerontol. A Biol. Sci. Med. Sci. 2006, 61, 399–404. [Google Scholar] [CrossRef]
- Adam, C.E.; Fitzpatrick, A.L.; Leary, C.S.; Ilango, S.D.; Phelan, E.A.; Semmens, E.O. The impact of falls on activities of daily living in older adults: A retrospective cohort analysis. PLoS ONE 2024, 19, e0294017. [Google Scholar] [CrossRef]
- Smith, L.; Shin, J.I.; López Sánchez, G.F.; Kostev, K.; Jacob, L.; Tully, M.A.; Butler, L.; Barnett, Y.; Veronese, N.; Soysal, P.; et al. Physical multimorbidity, suicidal ideation, and suicide attempts among adults aged ≥50 years from low- and middle-income countries. Int. J. Geriatr. Psychiatry 2023, 38, e5873. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Shin, J.; Kim, G.S. Patterns of change and factors associated with IADL function decline in community-dwelling older adults with arthritis. Sci. Rep. 2022, 12, 16840. [Google Scholar] [CrossRef] [PubMed]
- Manini, T.M.; Pahor, M. Physical activity and maintaining physical function in older adults. Br. J. Sports Med. 2009, 43, 28–31. [Google Scholar] [CrossRef] [PubMed]
- Fujii, K.; Fujii, Y.; Kitano, N.; Sato, A.; Hotta, K.; Okura, T. Mediating role of instrumental activities of daily living ability on cognitive function of older adults living alone: A 4-year longitudinal study from the Kasama study. Medicine 2021, 100, e27416. [Google Scholar] [CrossRef] [PubMed]
- Zhang, T.; Yang, C.; Shu, G.; Gao, C.; Ma, H.; Zou, L.; Zuo, J.; Liu, S.; Yan, J.; Hu, Y. The direct and mediating effects of cognitive impairment on the occurrence of falls: A cohort study based on community-dwelling old adults. Front. Med. 2023, 10, 1190831. [Google Scholar] [CrossRef]
- Han, D.; Li, S.; Wu, Y.; Zhao, J.; Zhang, M.; Liao, H.; Ma, Y.; Yan, C.; Wang, J. The mediating role of depression in the association between hearing impairment and functional disability among middle-aged and older adults in China. Innov. Aging 2023, 7, igad093. [Google Scholar] [CrossRef]
- Nguyen, V.C.; Moon, S.; Oh, E.; Hong, G.-R.S. Factors associated with functional limitations in daily living among older adults in Korea: A cross-sectional study. Int. J. Public Health 2022, 67, 1605155. [Google Scholar] [CrossRef]
- Samper-Ternent, R.; Gonzalez-Gonzalez, C.; Zazueta, J.D.; Wong, R. Factors associated with pain at the end-of-life among older adults in Mexico. Public Health 2021, 191, 68–77. [Google Scholar] [CrossRef]
- Garcia Meneguci, C.A.; Meneguci, J.; Sasaki, J.E.; Tribess, S.; Júnior, J.S.V. Physical activity, sedentary behavior and functional-ity in older adults: A cross-sectional path analysis. PLoS ONE 2021, 16, e0246275. [Google Scholar] [CrossRef]
- Chen, L.Y.; Fang, T.J.; Lin, Y.C.; Hsieh, H.F. Exploring the mediating effects of cognitive function, social support, activities of daily living and depression in the relationship between age and frailty among community-dwelling elderly. Int. J. Environ. Res. Public Health 2021, 18, 12543. [Google Scholar] [CrossRef]
- Wang, S.T.; Ni, G.X. Depression in osteoarthritis: Current understanding. Neuropsychiatr. Dis. Treat. 2022, 18, 375–389. [Google Scholar] [CrossRef]
- Greenblatt-Kimron, L.; Kestler-Peleg, M.; Even-Zohar, A.; Lavenda, O. Death anxiety and loneliness among older adults: Role of parental self-efficacy. Int. J. Environ. Res. Public Health 2021, 18, 9857. [Google Scholar] [CrossRef]
- Wei, J.; Hou, R.; Zhang, X.; Xu, H.; Xie, L. The association of late-life depression with all-cause and cardiovascular mortality among community-dwelling older adults: Systematic review and meta-analysis. Br. J. Psychiatry 2019, 215, 449–455. [Google Scholar] [CrossRef]
Characteristics | Categories | N (%) | Death Preparation | |
---|---|---|---|---|
M ± SD | t/F(p) | |||
Scheffé | ||||
Gender | Male | 244 (16.5) | 1.15 (1.10) | 1.02 (0.307) |
Female | 1239 (83.5) | 1.07 (1.01) | ||
Education level | ≤Elementary school | 930 (62.7) | 1.09 (1.01) | 0.22 (0.795) |
Middle school | 290 (19.6) | 1.05 (1.02) | ||
≥High school | 263 (17.7) | 1.09 (1.07) | ||
Satisfaction with economic conditions | Satisfied | 357 (24.6) | 1.16 (1.07) | 4.13 (0.016) |
Moderate | 668 (46.0) | 1.12 (0.99) | ||
Unsatisfied | 427 (29.4) | 0.97 (1.01) | ||
Living with spouse | Yes | 663 (44.7) | 1.13 (1.11) | 1.56 (0.118) |
No | 820 (55.3) | 1.05 (0.93) | ||
Relationship satisfaction with spouse | Satisfied | 405 (61.8) | 1.06 (1.08) | 2.01 (0.136) |
Moderate | 214 (32.7) | 1.25 (0.08) | ||
Unsatisfied | 36 (5.5) | 1.16 (0.84) | ||
Relationship satisfaction with children | Satisfied | 954 (68.5) | 1.12 (1.04) | 0.64 (0.523) |
Moderate | 337 (24.2) | 1.08 (1.02) | ||
Unsatisfied | 101 (7.3) | 1.01 (0.94) | ||
Satisfaction with relationships with friends and community | Satisfied | 743 (50.2) | 1.10 (1.01) | 0.29 (0.741) |
Moderate | 565 (38.1) | 1.08 (0.94) | ||
Unsatisfied | 142 (9.6) | 1.03 (1.30) | ||
Intention for life-sustaining treatment | Yes | 156 (10.8) | 1.08 (0.96) | 0.12 (0.99) |
No | 1296 (89.2) | 1.08 (1.02) | ||
Number of chronic diseases | 1 | 175 (11.8) | 0.97 (0.98) | 2.14 (0.118) |
2 | 404 (27.2) | 1.04 (1.03) | ||
≥3 | 904 (61.0) | 1.13 (1.02) | ||
Fall experience in the past year | Yes | 177 (11.9) | 1.26 (1.22) | 2.07 (0.039) |
No | 1306 (88.1) | 1.06 (0.99) | ||
Suicidal ideation | Yes | 50 (3.4) | 1.54 (1.59) | 2.05 (0.045) |
No | 1402 (96.6) | 1.07 (0.99) |
Variables | Ability to Perform Movement | Death Preparation | IADL | Depression |
---|---|---|---|---|
r(p) | r(p) | r(p) | r(p) | |
Ability to perform movement | 1 | |||
Death preparation | 0.11 (<0.001) | 1 | ||
IADL | 0.41 (<0.001) | 0.13 (<0.001) | 1 | |
Depression | 0.30 (<0.001) | 0.08 (0.001) | 0.35 (<0.001) | 1 |
No. | Variables | B (Coeffect) | SE | p | 95% CI | R2 | |||
---|---|---|---|---|---|---|---|---|---|
LLCI | ULCI | ||||||||
1 | Ability to perform movements | → | IADL | 0.312 | 0.020 | <0.001 | 0.272 | 0.352 | 0.139 |
2 | Ability to perform movements | → | Depression | 0.183 | 0.023 | <0.001 | 0.136 | 0.229 | 0.159 |
IADL | → | Depression | 0.299 | 0.028 | <0.001 | 0.244 | 0.355 | ||
3 | Ability to perform movements | → | Death preparation | 0.015 | 0.006 | 0.023 | 0.002 | 0.028 | 0.024 |
IADL | → | Death preparation | 0.028 | 0.008 | 0.001 | 0.013 | 0.044 | ||
Depression | → | Death preparation | 0.008 | 0.007 | 0.250 | −0.005 | 0.022 | ||
4 | Ability to perform movements | → | Death preparation | 0.026 | 0.006 | <0.001 | 0.014 | 0.038 | 0.012 |
Effect | SE | p | 95% CI | ||
---|---|---|---|---|---|
LLCI | ULCI | ||||
Total effect | 0.026 | 0.006 | <0.001 | 0.014 | 0.038 |
Direct effect | 0.015 | 0.006 | 0.023 | 0.002 | 0.028 |
Variables | Effect | Boot SE | 95% CI | ||
---|---|---|---|---|---|
LLCI | ULCI | ||||
Indirect 1 | Ability to perform movements → IADL→ Death preparation | 0.009 | 0.003 | 0.002 | 0.163 |
Indirect 2 | Ability to perform movements → Depression→ Death preparation | 0.001 | 0.001 | −0.001 | 0.004 |
Indirect 3 | Ability to perform movements → IADL → Depression → Death preparation | 0.001 | 0.001 | −0.001 | 0.002 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Kwon, M.; Kim, S.A.; Kim, J. Mediating Effect of IADL and Depression in the Relationship Between Ability to Perform Movements and Death Preparation in Elderly with Osteoarthritis or Rheumatoid Arthritis. Healthcare 2025, 13, 513. https://doi.org/10.3390/healthcare13050513
Kwon M, Kim SA, Kim J. Mediating Effect of IADL and Depression in the Relationship Between Ability to Perform Movements and Death Preparation in Elderly with Osteoarthritis or Rheumatoid Arthritis. Healthcare. 2025; 13(5):513. https://doi.org/10.3390/healthcare13050513
Chicago/Turabian StyleKwon, Myoungjin, Sun Ae Kim, and Jiyoung Kim. 2025. "Mediating Effect of IADL and Depression in the Relationship Between Ability to Perform Movements and Death Preparation in Elderly with Osteoarthritis or Rheumatoid Arthritis" Healthcare 13, no. 5: 513. https://doi.org/10.3390/healthcare13050513
APA StyleKwon, M., Kim, S. A., & Kim, J. (2025). Mediating Effect of IADL and Depression in the Relationship Between Ability to Perform Movements and Death Preparation in Elderly with Osteoarthritis or Rheumatoid Arthritis. Healthcare, 13(5), 513. https://doi.org/10.3390/healthcare13050513