The Link between Dietary Protein Intake, Skeletal Muscle Function and Health in Older Adults
Abstract
:1. Introduction
2. Dietary Guidelines for Protein Intake: Current Recommendations May Underestimate Optimal Intake in Older Adults
2.1. Current Guidelines for Protein Intake
Recommendation | Gram protein/kg body weight/day |
---|---|
EAR | 0.66 |
RDA | 0.8 |
AMDR * | ~1.05–3.67 |
2.2. Quantity versus Quality of Protein Intake
2.3. Timing of Protein Intake
3. Functional Benefits of Protein in Older Adults
3.1. The Role of Leucine in Older Adults
3.2. Increased Muscle Protein Synthesis and Leucine Intake in Older Adults
4. Risk Factors Associated with Low Protein Intake
5. Clinical and Financial Impact of Nutrition in the Older Adults
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
- Centers for Disease Control and Prevention, U.S. Department of Health and Human Services. The State of Aging and Health in America 2013; CreateSpace Independent Publishing Platform: Denver, CO, USA, 2013. [Google Scholar]
- Wolfe, R.R. The role of dietary protein in optimizing muscle mass, function and health outcomes in older individuals. Br. J. Nutr. 2012, 108, S88–S93. [Google Scholar] [CrossRef] [PubMed]
- Arthur, S.T.; Cooley, I.D. The effect of physiological stimuli on sarcopenia; impact of notch and Wnt signaling on impaired aged skeletal muscle repair. Int. J. Biol. Sci. 2012, 8, 731–760. [Google Scholar] [CrossRef] [PubMed]
- Kim, T.N.; Choi, K.M. Sarcopenia: Definition, epidemiology, and pathophysiology. J. Bone Metab. 2013, 20, 1–10. [Google Scholar] [CrossRef] [PubMed]
- Wolfe, R.R.; Miller, S.L.; Miller, K.B. Optimal protein intake in the elderly. Clin. Nutr. 2008, 27, 675–684. [Google Scholar] [CrossRef] [PubMed]
- Guller, I.; Russell, A.P. MicroRNAs in skeletal muscle: Their role and regulation in development, disease and function. J. Physiol. 2010, 588, 4075–4087. [Google Scholar] [CrossRef] [PubMed]
- Chumlea, W.C.; Baumgartner, R.N.; Vellas, B.P. Anthropometry and body composition in the perspective of nutritional status in the elderly. Nutrition 1991, 7, 57–60. [Google Scholar] [PubMed]
- Kim, T.N.; Won, J.C.; Kim, Y.J.; Lee, E.J.; Kim, M.K.; Park, M.S.; Lee, S.K.; Kim, J.M.; Ko, K.S.; Rhee, B.D. Serum adipocyte fatty acid-binding protein levels are independently associated with sarcopenic obesity. Diabetes Res. Clin. Pract. 2013, 101, 210–217. [Google Scholar] [CrossRef] [PubMed]
- Morais, J.A.; Chevalier, S.; Gougeon, R. Protein turnover and requirements in the healthy and frail elderly. J. Nutr. Health Aging 2006, 10, 272–283. [Google Scholar] [PubMed]
- Wilson, M.M.; Purushothaman, R.; Morley, J.E. Effect of liquid dietary supplements on energy intake in the elderly. Am. J. Clin. Nutr. 2002, 75, 944–947. [Google Scholar] [PubMed]
- Dawson-Hughes, B. Calcium and protein in bone health. Proc. Nutr. Soc. 2003, 62, 505–509. [Google Scholar] [CrossRef] [PubMed]
- Dawson-Hughes, B. Interaction of dietary calcium and protein in bone health in humans. J. Nutr. 2003, 133, 852S–854S. [Google Scholar] [PubMed]
- Thorpe, M.P.; Jacobson, E.H.; Layman, D.K.; He, X.; Kris-Etherton, P.M.; Evans, E.M. A diet high in protein, dairy, and calcium attenuates bone loss over twelve months of weight loss and maintenance relative to a conventional high-carbohydrate diet in adults. J. Nutr. 2008, 138, 1096–1100. [Google Scholar] [PubMed]
- Heaney, R.P.; Layman, D.K. Amount and type of protein influences bone health. Am. J. Clin. Nutr. 2008, 87, 1567S–1570S. [Google Scholar] [PubMed]
- Hu, F.B.; Stampfer, M.J.; Manson, J.E.; Rimm, E.; Colditz, G.A.; Speizer, F.E.; Hennekens, C.H.; Willett, W.C. Dietary protein and risk of ischemic heart disease in women. Am. J. Clin. Nutr. 1999, 70, 221–227. [Google Scholar] [PubMed]
- Obarzanek, E.; Velletri, P.A.; Cutler, J.A. Dietary protein and blood pressure. Jama 1996, 275, 1598–1603. [Google Scholar] [CrossRef] [PubMed]
- Stamler, J.; Elliott, P.; Kesteloot, H.; Nichols, R.; Claeys, G.; Dyer, A.R.; Stamler, R. Inverse relation of dietary protein markers with blood pressure. Findings for 10,020 men and women in the INTERSALT Study. INTERSALT Cooperative Research Group. INTERnational study of SALT and blood pressure. Circulation 1996, 94, 1629–1634. [Google Scholar] [CrossRef] [PubMed]
- Stratton, R.J.; Ek, A.C.; Engfer, M.; Moore, Z.; Rigby, P.; Wolfe, R.; Elia, M. Enteral nutritional support in prevention and treatment of pressure ulcers: A systematic review and meta-analysis. Ageing Res. Rev. 2005, 4, 422–450. [Google Scholar] [CrossRef] [PubMed]
- U.S. Department of Agriculture; U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 7th ed.U.S. Government Printing Office: Washington, DC, USA, 2010.
- Trumbo, P.; Schlicker, S.; Yates, A.A.; Poos, M.; Food and Nutrition Board of the Institute of Medicine; The National Academies. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids; National Academy Press: Washington, DC, USA, 2002. [Google Scholar]
- Campbell, W.W.; Crim, M.C.; Dallal, G.E.; Young, V.R.; Evans, W.J. Increased protein requirements in elderly people: New data and retrospective reassessments. Am. J. Clin. Nutr. 1994, 60, 501–509. [Google Scholar] [PubMed]
- Volpi, E.; Campbell, W.W.; Dwyer, J.T.; Johnson, M.A.; Jensen, G.L.; Morley, J.E.; Wolfe, R.R. Is the optimal level of protein intake for older adults greater than the recommended dietary allowance? J. Gerontol. A Biol. Sci. Med. Sci. 2013, 68, 677–681. [Google Scholar] [CrossRef] [PubMed]
- Millward, D.J.; Layman, D.K.; Tome, D.; Schaafsma, G. Protein quality assessment: Impact of expanding understanding of protein and amino acid needs for optimal health. Am. J. Clin. Nutr. 2008, 87, 1576S–1581S. [Google Scholar] [PubMed]
- Anthony, J.C.; Anthony, T.G.; Kimball, S.R.; Vary, T.C.; Jefferson, L.S. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J. Nutr. 2000, 130, 139–145. [Google Scholar] [PubMed]
- Anthony, J.C.; Yoshizawa, F.; Anthony, T.G.; Vary, T.C.; Jefferson, L.S.; Kimball, S.R. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J. Nutr. 2000, 130, 2413–2419. [Google Scholar] [PubMed]
- Gordon, B.S.; Kelleher, A.R.; Kimball, S.R. Regulation of muscle protein synthesis and the effects of catabolic states. Int. J. Biochem. Cell Biol. 2013, 45, 2147–2157. [Google Scholar] [CrossRef] [PubMed]
- Wolfe, R.R. Regulation of muscle protein by amino acids. J. Nutr. 2002, 132, 3219S–3224S. [Google Scholar] [PubMed]
- Borsheim, E.; Tipton, K.D.; Wolf, S.E.; Wolfe, R.R. Essential amino acids and muscle protein recovery from resistance exercise. Am. J. Physiol. Endocrinol. Metab. 2002, 283, E648–E657. [Google Scholar] [CrossRef] [PubMed]
- Mitchell, C.J.; Della Gatta, P.A.; Petersen, A.C.; Cameron-Smith, D.; Markworth, J.F. Soy protein ingestion results in less prolonged p70S6 kinase phosphorylation compared to whey protein after resistance exercise in older men. J. Int. Soc. Sports Nutr. 2015. [Google Scholar] [CrossRef] [PubMed]
- Phillips, S.M.; Tang, J.E.; Moore, D.R. The role of milk- and soy-based protein in support of muscle protein synthesis and muscle protein accretion in young and elderly persons. J. Am. Coll. Nutr. 2009, 28, 343–354. [Google Scholar] [CrossRef] [PubMed]
- Tang, J.E.; Moore, D.R.; Kujbida, G.W.; Tarnopolsky, M.A.; Phillips, S.M. Ingestion of whey hydrolysate, casein, or soy protein isolate: Effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J. Appl. Physiol. 1985 2009, 107, 987–992. [Google Scholar] [CrossRef] [PubMed]
- Houston, D.K.; Nicklas, B.J.; Ding, J.; Harris, T.B.; Tylavsky, F.A.; Newman, A.B.; Lee, J.S.; Sahyoun, N.R.; Visser, M.; Kritchevsky, S.B. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: The Health, Aging, and Body Composition (Health ABC) Study. Am. J. Clin. Nutr. 2008, 87, 150–155. [Google Scholar] [PubMed]
- Tieland, M.; van de Rest, O.; Dirks, M.L.; van der Zwaluw, N.; Mensink, M.; van Loon, L.J.; de Groot, L.C. Protein supplementation improves physical performance in frail elderly people: A randomized, double-blind, placebo-controlled trial. J. Am. Med. Dir. Assoc. 2012, 13, 720–726. [Google Scholar] [CrossRef] [PubMed]
- Tieland, M.; Dirks, M.L.; van der Zwaluw, N.; Verdijk, L.B.; van de Rest, O.; de Groot, L.C.; van Loon, L.J. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: A randomized, double-blind, placebo-controlled trial. J. Am. Med. Dir. Assoc. 2012, 13, 713–719. [Google Scholar] [CrossRef] [PubMed]
- Wolfe, R.R. Perspective: Optimal protein intake in the elderly. J. Am. Med. Dir. Assoc. 2013, 14, 65–66. [Google Scholar] [CrossRef] [PubMed]
- Boirie, Y.; Dangin, M.; Gachon, P.; Vasson, M.P.; Maubois, J.L.; Beaufrere, B. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc. Natl. Acad. Sci. USA 1997, 94, 14930–14935. [Google Scholar] [CrossRef] [PubMed]
- Dangin, M.; Boirie, Y.; Garcia-Rodenas, C.; Gachon, P.; Fauquant, J.; Callier, P.; Ballevre, O.; Beaufrere, B. The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am. J. Physiol. Endocrinol. Metab. 2001, 280, E340–E348. [Google Scholar] [PubMed]
- Dangin, M.; Boirie, Y.; Guillet, C.; Beaufrere, B. Influence of the protein digestion rate on protein turnover in young and elderly subjects. J. Nutr. 2002, 132, 3228S–3233S. [Google Scholar] [PubMed]
- Pennings, B.; Boirie, Y.; Senden, J.M.; Gijsen, A.P.; Kuipers, H.; van Loon, L.J. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am. J. Clin. Nutr. 2011, 93, 997–1005. [Google Scholar] [CrossRef] [PubMed]
- Boirie, Y.; Gachon, P.; Beaufrere, B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am. J. Clin. Nutr. 1997, 65, 489–495. [Google Scholar] [PubMed]
- Paddon-Jones, D.; Sheffield-Moore, M.; Katsanos, C.S.; Zhang, X.J.; Wolfe, R.R. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp. Gerontol. 2006, 41, 215–219. [Google Scholar] [CrossRef] [PubMed]
- Pennings, B.; Groen, B.B.; van Dijk, J.W.; de Lange, A.; Kiskini, A.; Kuklinski, M.; Senden, J.M.; van Loon, L.J. Minced beef is more rapidly digested and absorbed than beef steak, resulting in greater postprandial protein retention in older men. Am. J. Clin. Nutr. 2013, 98, 121–128. [Google Scholar] [CrossRef] [PubMed]
- Layman, D.K.; Baum, J.I. Dietary protein impact on glycemic control during weight loss. J. Nutr. 2004, 134, 968S–973S. [Google Scholar] [PubMed]
- Layman, D.K. The role of leucine in weight loss diets and glucose homeostasis. J. Nutr. 2003, 133, 261S–267S. [Google Scholar] [PubMed]
- Layman, D.K. Role of leucine in protein metabolism during exercise and recovery. Can. J. Appl. Physiol. 2002, 27, 646–663. [Google Scholar] [CrossRef] [PubMed]
- Katsanos, C.S.; Kobayashi, H.; Sheffield-Moore, M.; Aarsland, A.; Wolfe, R.R. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am. J. Physiol. Endocrinol. Metab. 2006, 291, E381–E387. [Google Scholar] [CrossRef] [PubMed]
- Anthony, J.C.; Reiter, A.K.; Anthony, T.G.; Crozier, S.J.; Lang, C.H.; MacLean, D.A.; Kimball, S.R.; Jefferson, L.S. Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes 2002, 51, 928–936. [Google Scholar] [CrossRef] [PubMed]
- Norton, L.E.; Layman, D.K.; Bunpo, P.; Anthony, T.G.; Brana, D.V.; Garlick, P.J. The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats. J. Nutr. 2009, 139, 1103–1109. [Google Scholar] [CrossRef] [PubMed]
- Layman, D.K.; Boileau, R.A.; Erickson, D.J.; Painter, J.E.; Shiue, H.; Sather, C.; Christou, D.D. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. J. Nutr. 2003, 133, 411–417. [Google Scholar] [PubMed]
- Layman, D.K.; Shiue, H.; Sather, C.; Erickson, D.J.; Baum, J. Increased dietary protein modifies glucose and insulin homeostasis in adult women during weight loss. J. Nutr. 2003, 133, 405–410. [Google Scholar] [PubMed]
- Layman, D.K.; Evans, E.M.; Erickson, D.; Seyler, J.; Weber, J.; Bagshaw, D.; Griel, A.; Psota, T.; Kris-Etherton, P. A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults. J. Nutr. 2009, 139, 514–521. [Google Scholar] [CrossRef] [PubMed]
- Moore, D.R.; Churchward-Venne, T.A.; Witard, O.; Breen, L.; Burd, N.A.; Tipton, K.D.; Phillips, S.M. Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men. J. Gerontol. A Biol. Sci. Med. Sci. 2015, 70, 57–62. [Google Scholar] [CrossRef] [PubMed]
- Fulgoni, V.L., 3rd. Current protein intake in America: Analysis of the National Health and Nutrition Examination Survey, 2003–2004. Am. J. Clin. Nutr. 2008, 87, 1554S–1557S. [Google Scholar] [PubMed]
- Symons, T.B.; Sheffield-Moore, M.; Wolfe, R.R.; Paddon-Jones, D. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J. Am. Diet. Assoc. 2009, 109, 1582–1586. [Google Scholar] [CrossRef] [PubMed]
- Mamerow, M.M.; Mettler, J.A.; English, K.L.; Casperson, S.L.; Arentson-Lantz, E.; Sheffield-Moore, M.; Layman, D.K.; Paddon-Jones, D. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J. Nutr. 2014, 144, 876–880. [Google Scholar] [CrossRef] [PubMed]
- Murphy, C.H.; Churchward-Venne, T.A.; Mitchell, C.J.; Kolar, N.M.; Kassis, A.; Karagounis, L.G.; Burke, L.M.; Hawley, J.A.; Phillips, S.M. Hypoenergetic diet-induced reductions in myofibrillar protein synthesis are restored with resistance training and balanced daily protein ingestion in older men. Am. J. Physiol. Endocrinol. Metab. 2015, 308, E734–E743. [Google Scholar] [CrossRef] [PubMed]
- Kim, I.Y.; Schutzler, S.; Schrader, A.; Spencer, H.; Kortebein, P.; Deutz, N.E.; Wolfe, R.R.; Ferrando, A.A. Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults. Am. J. Physiol. Endocrinol. Metab. 2015, 308, E21–E28. [Google Scholar] [CrossRef] [PubMed]
- Arnal, M.A.; Mosoni, L.; Boirie, Y.; Houlier, M.L.; Morin, L.; Verdier, E.; Ritz, P.; Antoine, J.M.; Prugnaud, J.; Beaufrere, B.; et al. Protein pulse feeding improves protein retention in elderly women. Am. J. Clin. Nutr. 1999, 69, 1202–1208. [Google Scholar] [PubMed]
- Bouillanne, O.; Neveux, N.; Nicolis, I.; Curis, E.; Cynober, L.; Aussel, C. Long-lasting improved amino acid bioavailability associated with protein pulse feeding in hospitalized elderly patients: A randomized controlled trial. Nutrition 2014, 30, 544–550. [Google Scholar] [CrossRef] [PubMed]
- Bouillanne, O.; Curis, E.; Hamon-Vilcot, B.; Nicolis, I.; Chretien, P.; Schauer, N.; Vincent, J.P.; Cynober, L.; Aussel, C. Impact of protein pulse feeding on lean mass in malnourished and at-risk hospitalized elderly patients: A randomized controlled trial. Clin. Nutr. 2013, 32, 186–192. [Google Scholar] [CrossRef] [PubMed]
- Wall, B.T.; Hamer, H.M.; de Lange, A.; Kiskini, A.; Groen, B.B.; Senden, J.M.; Gijsen, A.P.; Verdijk, L.B.; van Loon, L.J. Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men. Clin. Nutr. 2013, 32, 412–419. [Google Scholar] [CrossRef] [PubMed]
- Casperson, S.L.; Sheffield-Moore, M.; Hewlings, S.J.; Paddon-Jones, D. Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein. Clin. Nutr. 2012, 31, 512–519. [Google Scholar] [CrossRef] [PubMed]
- Rasmussen, B.B.; Wolfe, R.R.; Volpi, E. Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly. J. Nutr. Health Aging 2002, 6, 358–362. [Google Scholar] [PubMed]
- Cuthbertson, D.; Smith, K.; Babraj, J.; Leese, G.; Waddell, T.; Atherton, P.; Wackerhage, H.; Taylor, P.M.; Rennie, M.J. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005, 19, 422–424. [Google Scholar] [CrossRef] [PubMed]
- Sakuma, K.; Aoi, W.; Yamaguchi, A. Current understanding of sarcopenia: Possible candidates modulating muscle mass. Pflugers Arch. 2015, 467, 213–229. [Google Scholar] [CrossRef] [PubMed]
- Sakuma, K.; Aoi, W.; Yamaguchi, A. The intriguing regulators of muscle mass in sarcopenia and muscular dystrophy. Front. Aging Neurosci. 2014. [Google Scholar] [CrossRef] [PubMed]
- Kimball, S.R.; Jefferson, L.S. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J. Nutr. 2006, 136, 227S–231S. [Google Scholar] [PubMed]
- Kimball, S.R.; Jefferson, L.S. Role of amino acids in the translational control of protein synthesis in mammals. Semin. Cell Dev. Biol. 2005, 16, 21–27. [Google Scholar] [CrossRef] [PubMed]
- Kimball, S.R.; Jefferson, L.S. Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids. Biochem. Biophys. Res. Commun. 2004, 313, 423–427. [Google Scholar] [CrossRef] [PubMed]
- Wilkinson, D.J.; Hossain, T.; Hill, D.S.; Phillips, B.E.; Crossland, H.; Williams, J.; Loughna, P.; Churchward-Venne, T.A.; Breen, L.; Phillips, S.M.; et al. Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. J. Physiol. 2013, 591, 2911–2923. [Google Scholar] [CrossRef] [PubMed]
- Katsanos, C.S.; Kobayashi, H.; Sheffield-Moore, M.; Aarsland, A.; Wolfe, R.R. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am. J. Clin. Nutr. 2005, 82, 1065–1073. [Google Scholar] [PubMed]
- Paddon-Jones, D.; Sheffield-Moore, M.; Creson, D.L.; Sanford, A.P.; Wolf, S.E.; Wolfe, R.R.; Ferrando, A.A. Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids. Am. J. Physiol. Endocrinol. Metab. 2003, 284, E946–E953. [Google Scholar] [CrossRef] [PubMed]
- Guillet, C.; Prod’homme, M.; Balage, M.; Gachon, P.; Giraudet, C.; Morin, L.; Grizard, J.; Boirie, Y. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J. 2004, 18, 1586–1587. [Google Scholar] [CrossRef] [PubMed]
- Fry, C.S.; Drummond, M.J.; Glynn, E.L.; Dickinson, J.M.; Gundermann, D.M.; Timmerman, K.L.; Walker, D.K.; Volpi, E.; Rasmussen, B.B. Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults. J. Gerontol. A Biol. Sci. Med. Sci. 2013, 68, 599–607. [Google Scholar] [CrossRef] [PubMed]
- Drummond, M.J.; Miyazaki, M.; Dreyer, H.C.; Pennings, B.; Dhanani, S.; Volpi, E.; Esser, K.A.; Rasmussen, B.B. Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis. J. Appl. Physiol. 1985 2009, 106, 1403–1411. [Google Scholar] [CrossRef] [PubMed]
- Drummond, M.J.; Dickinson, J.M.; Fry, C.S.; Walker, D.K.; Gundermann, D.M.; Reidy, P.T.; Timmerman, K.L.; Markofski, M.M.; Paddon-Jones, D.; Rasmussen, B.B.; et al. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am. J. Physiol. Endocrinol. Metab. 2012, 302, E1113–E1122. [Google Scholar] [CrossRef] [PubMed]
- Kelijman, M. Age-related alterations of the growth hormone/insulin-like-growth-factor I axis. J. Am. Geriatr. Soc. 1991, 39, 295–307. [Google Scholar] [CrossRef] [PubMed]
- Ceda, G.P.; Dall’Aglio, E.; Maggio, M.; Lauretani, F.; Bandinelli, S.; Falzoi, C.; Grimaldi, W.; Ceresini, G.; Corradi, F.; Ferrucci, L.; et al. Clinical implications of the reduced activity of the GH-IGF-I axis in older men. J. Endocrinol. Investig. 2005, 28, 96–100. [Google Scholar]
- Schurch, M.A.; Rizzoli, R.; Slosman, D.; Vadas, L.; Vergnaud, P.; Bonjour, J.P. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 1998, 128, 801–809. [Google Scholar] [CrossRef] [PubMed]
- Morley, J.E. Anorexia, weight loss, and frailty. J. Am. Med. Dir. Assoc. 2010, 11, 225–228. [Google Scholar] [CrossRef] [PubMed]
- Locher, J.L.; Ritchie, C.S.; Roth, D.L.; Sen, B.; Vickers, K.S.; Vailas, L.I. Food choice among homebound older adults: Motivations and perceived barriers. J. Nutr. Health Aging 2009, 13, 659–664. [Google Scholar] [CrossRef] [PubMed]
- Wolfe, R.R. The underappreciated role of muscle in health and disease. Am. J. Clin. Nutr. 2006, 84, 475–482. [Google Scholar] [PubMed]
- Keller, H.H. Malnutrition in institutionalized elderly: How and why? J. Am. Geriatr. Soc. 1993, 41, 1212–1218. [Google Scholar] [CrossRef] [PubMed]
- Morley, J.E. Anorexia of aging: Physiologic and pathologic. Am. J. Clin. Nutr. 1997, 66, 760–773. [Google Scholar] [PubMed]
- Paddon-Jones, D.; Sheffield-Moore, M.; Zhang, X.J.; Volpi, E.; Wolf, S.E.; Aarsland, A.; Ferrando, A.A.; Wolfe, R.R. Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am. J. Physiol. Endocrinol. Metab. 2004, 286, E321–E328. [Google Scholar] [CrossRef] [PubMed]
- Volpi, E.; Ferrando, A.A.; Yeckel, C.W.; Tipton, K.D.; Wolfe, R.R. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J. Clin. Investig. 1998, 101, 2000–2007. [Google Scholar] [CrossRef] [PubMed]
- Demling, R.H.; DeSanti, L. Increased protein intake during the recovery phase after severe burns increases body weight gain and muscle function. J. Burn Care Rehabil. 1998, 19, 161–168. [Google Scholar] [CrossRef] [PubMed]
- Hughes, M.S.; Kazmier, P.; Burd, T.A.; Anglen, J.; Stoker, A.M.; Kuroki, K.; Carson, W.L.; Cook, J.L. Enhanced fracture and soft-tissue healing by means of anabolic dietary supplementation. J. Bone Jt. Surg. Am. 2006, 88, 2386–2394. [Google Scholar] [CrossRef] [PubMed]
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Baum, J.I.; Wolfe, R.R. The Link between Dietary Protein Intake, Skeletal Muscle Function and Health in Older Adults. Healthcare 2015, 3, 529-543. https://doi.org/10.3390/healthcare3030529
Baum JI, Wolfe RR. The Link between Dietary Protein Intake, Skeletal Muscle Function and Health in Older Adults. Healthcare. 2015; 3(3):529-543. https://doi.org/10.3390/healthcare3030529
Chicago/Turabian StyleBaum, Jamie I., and Robert R. Wolfe. 2015. "The Link between Dietary Protein Intake, Skeletal Muscle Function and Health in Older Adults" Healthcare 3, no. 3: 529-543. https://doi.org/10.3390/healthcare3030529
APA StyleBaum, J. I., & Wolfe, R. R. (2015). The Link between Dietary Protein Intake, Skeletal Muscle Function and Health in Older Adults. Healthcare, 3(3), 529-543. https://doi.org/10.3390/healthcare3030529