Regulatory Role of Orexin in the Antistress Effect of “Press Tack Needle” Acupuncture Treatment

Fujiwara, Aki; Tsukada, Mana; Ikemoto, Hideshi; Izuno, Takuji; Hattori, Satoshi; Okumo, Takayuki; Hisamitsu, Tadashi; Sunagawa, Masataka

doi:10.3390/healthcare9050503

Open AccessArticle

Regulatory Role of Orexin in the Antistress Effect of “Press Tack Needle” Acupuncture Treatment

by

Aki Fujiwara

^1,2,

Mana Tsukada

¹,

Hideshi Ikemoto

¹

,

Takuji Izuno

¹,

Satoshi Hattori

¹,

Takayuki Okumo

¹

,

Tadashi Hisamitsu

¹

and

Masataka Sunagawa

^1,*

¹

Department of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan

²

Acupuncture & Moxibustion Clinic Tenshinotamago, Tokyo 104-0061, Japan

^*

Author to whom correspondence should be addressed.

Healthcare 2021, 9(5), 503; https://doi.org/10.3390/healthcare9050503

Submission received: 17 February 2021 / Revised: 16 April 2021 / Accepted: 22 April 2021 / Published: 27 April 2021

Download

Browse Figures

Review Reports Versions Notes

Abstract

The aim of this research was to investigate the antistress effect of press tack needle (PTN) acupuncture treatment using rats with social isolation stress (SIS). Rats were divided into non-stress group (Grouped+sham), stress group (SIS+sham), and PTN-treated SIS group (SIS+PTN). Rats in the SIS+PTN and SIS+sham groups were housed alone for eight days. For the SIS+PTN group, a PTN (length, 0.3 or 1.2 mm) was fixed on the GV20 acupoint on day 7. We measured stress behavior based on the time the rats showed aggressive behavior and the levels of plasma corticosterone and orexin A on day 8. In addition, the orexin-1 receptor or orexin-2 receptor antagonist was administered to rats that were exposed to SIS. The duration of aggressive behavior was significantly prolonged in the SIS+sham group, and the prolonged duration was inhibited in the SIS+PTN (1.2 mm) group. The levels of plasma corticosterone and orexin A were significantly increased in the SIS+sham group; however, these increases were inhibited in the SIS+PTN group. The aggressive behavior was significantly reduced after the orexin-2 receptor antagonist was administered. These findings suggest that PTN treatment at GV20 may have an antistress effect, and the control of orexin is a mechanism underlying this phenomenon.

Keywords: orexin; acupuncture; press tack needle; antistress effect; orexin receptor; aggressive behavior

Share and Cite

MDPI and ACS Style

Fujiwara, A.; Tsukada, M.; Ikemoto, H.; Izuno, T.; Hattori, S.; Okumo, T.; Hisamitsu, T.; Sunagawa, M. Regulatory Role of Orexin in the Antistress Effect of “Press Tack Needle” Acupuncture Treatment. Healthcare 2021, 9, 503. https://doi.org/10.3390/healthcare9050503

AMA Style

Fujiwara A, Tsukada M, Ikemoto H, Izuno T, Hattori S, Okumo T, Hisamitsu T, Sunagawa M. Regulatory Role of Orexin in the Antistress Effect of “Press Tack Needle” Acupuncture Treatment. Healthcare. 2021; 9(5):503. https://doi.org/10.3390/healthcare9050503

Chicago/Turabian Style

Fujiwara, Aki, Mana Tsukada, Hideshi Ikemoto, Takuji Izuno, Satoshi Hattori, Takayuki Okumo, Tadashi Hisamitsu, and Masataka Sunagawa. 2021. "Regulatory Role of Orexin in the Antistress Effect of “Press Tack Needle” Acupuncture Treatment" Healthcare 9, no. 5: 503. https://doi.org/10.3390/healthcare9050503

APA Style

Fujiwara, A., Tsukada, M., Ikemoto, H., Izuno, T., Hattori, S., Okumo, T., Hisamitsu, T., & Sunagawa, M. (2021). Regulatory Role of Orexin in the Antistress Effect of “Press Tack Needle” Acupuncture Treatment. Healthcare, 9(5), 503. https://doi.org/10.3390/healthcare9050503

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Regulatory Role of Orexin in the Antistress Effect of “Press Tack Needle” Acupuncture Treatment

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI