miR-671-5p Inhibition by MSI1 Promotes Glioblastoma Tumorigenesis via Radioresistance, Tumor Motility and Cancer Stem-like Cell Properties
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. miR-671-5p Is Downregulated by MSI1 in Glioblastoma
3.2. miR-671-5p Promotes Radiosensitivity by Suppressing DNA Repair, Cancer Stem-like Properties and Tumor Migration
3.3. Activation of the MSI1/miR-671-5p/STAT3 Axis Regulates Radiosensitivity
3.4. The MSI1/miR-671-5p/TRAF2 Axis Mediates EMT and CSC Abilities
3.5. miR-671-5p Is Inversely Related to Glioblastoma Tumorigenesis In Vivo
3.6. miR-671-5p Is Inversely Correlated with STAT3 Activation and TRAF2 Presentation in Clinical GBM
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Lin, J.-C.; Kuo, C.-Y.; Tsai, J.-T.; Liu, W.-H. miR-671-5p Inhibition by MSI1 Promotes Glioblastoma Tumorigenesis via Radioresistance, Tumor Motility and Cancer Stem-like Cell Properties. Biomedicines 2022, 10, 21. https://doi.org/10.3390/biomedicines10010021
Lin J-C, Kuo C-Y, Tsai J-T, Liu W-H. miR-671-5p Inhibition by MSI1 Promotes Glioblastoma Tumorigenesis via Radioresistance, Tumor Motility and Cancer Stem-like Cell Properties. Biomedicines. 2022; 10(1):21. https://doi.org/10.3390/biomedicines10010021
Chicago/Turabian StyleLin, Jang-Chun, Chun-Yuan Kuo, Jo-Ting Tsai, and Wei-Hsiu Liu. 2022. "miR-671-5p Inhibition by MSI1 Promotes Glioblastoma Tumorigenesis via Radioresistance, Tumor Motility and Cancer Stem-like Cell Properties" Biomedicines 10, no. 1: 21. https://doi.org/10.3390/biomedicines10010021