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Article
Peer-Review Record

Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans

Biomedicines 2022, 10(11), 2798; https://doi.org/10.3390/biomedicines10112798
by Yasmine Sommerer 1, Valerija Dobricic 1, Marcel Schilling 1, Olena Ohlei 1, David Bartrés-Faz 2, Gabriele Cattaneo 3,4,5, Ilja Demuth 6,7, Sandra Düzel 8, Sören Franzenburg 9, Janina Fuß 9, Ulman Lindenberger 8, Álvaro Pascual-Leone 3,10,11, Sanaz Sedghpour Sabet 9, Cristina Solé-Padullés 2, Josep M. Tormos 3,4,5, Valentin Max Vetter 6, Tanja Wesse 9, Andre Franke 9, Christina M. Lill 1,12,13 and Lars Bertram 1,14,*
Reviewer 1:
Reviewer 2: Anonymous
Biomedicines 2022, 10(11), 2798; https://doi.org/10.3390/biomedicines10112798
Submission received: 4 October 2022 / Revised: 24 October 2022 / Accepted: 26 October 2022 / Published: 3 November 2022
(This article belongs to the Special Issue Genetic Architecture of Dementia)

Round 1

Reviewer 1 Report

The paper is well written it concerns an Epigenome-wide association study in the peripheral tissue of AD patients with light DNA methylation profiles associated with episodic memory in humans. There are 2 figures and ethics approval the data is available under the GEO, references includes Hardy et al. 

minor comment  - conclusions section can be added 

Author Response

We would like to thank Reviewer 1 for his/her kind and positive approval of our study. As suggested, we have now added a concluding paragraph towards the end of our main text. This replaces the former "In summary..." paragraph which was shortened and adapted to better reflect the format of a conclusions paragraph.

Reviewer 2 Report

This is a very good study, carefully planned and performed. The only recommendation I can make is to add a flowchart of the study design and procedures as a supplementary figure. This is a good approach in situations when a design is complex. 

Author Response

We thank reviewer 2 for his/her very positive overall evaluation of our manuscript. We very much liked the idea of adding a flowchart to visually summarize the workflow of our study, thank you! As suggested, this has been added to the supplementary material of our manuscript.

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