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Biomedicines
Volume 10
Issue 12
10.3390/biomedicines10123162
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Review
Peer-Review Record

Overcoming Barriers to Preventing and Treating P. aeruginosa Infections Using AAV Vectored Immunoprophylaxis

Biomedicines 2022, 10(12), 3162; https://doi.org/10.3390/biomedicines10123162
by Jordyn A. Lopes 1, Amira D. Rghei 1, Brad Thompson 2, Leonardo Susta 1, Cezar M. Khursigara 3 and Sarah K. Wootton 1,*
Reviewer 1: Anonymous
Reviewer 2:
Mohammad Abrar Alam
Biomedicines 2022, 10(12), 3162; https://doi.org/10.3390/biomedicines10123162
Submission received: 18 November 2022 / Revised: 3 December 2022 / Accepted: 5 December 2022 / Published: 7 December 2022
(This article belongs to the Special Issue Advances and Challenges in the Study of Host-Pathogen Interactions)

Round 1

Reviewer 1 Report

In the manuscript “Overcoming barriers to preventing and treating P. aeruginosa infections using AAV vectored immunoprophylaxis” the authors evaluated the prevalence and antibiotic resistance of  P.aeruginosa. They analyzed the impact of P.aeruginosa-related infections on peopole, focusing their attention on patients with cystic fibrosis. The manuscript is well-structured and organized. it shows a detailed summary of issues related to infections caused by gram-negative bacteria, especially P.aeruginosa. It places increased attention on antibiotic resistance and the difficulty in treating bacterial infections, especially in frail patients.

 

Author Response

See attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript entitled "Overcoming barriers to preventing and treating P. aeruginosa infections using AAV vectored immunoprophylaxis" is very significant as the mentioned bacteria is one of the dreaded pathogens. I have the following comments before the manuscript gets accepted for publication.

1. Authors have discussed ESKAPE pathogens to the significance of the topic. P. aeruginosa is also a significant pathogen of SPEAKS pathogen, which have reported recently. Authors should cite these two papers and discuss the SPEAKS pathogens briefly.

a. https://www.mdpi.com/2079-6382/11/7/939

Antibiotics 2022, 11(7), 939; https://doi.org/10.3390/antibiotics11070939

b. https://www.sciencedirect.com/science/article/pii/S0140673621027240

2. There are many typos and minor corrections. Please find the attached file.

 

Comments for author File: Comments.pdf

Author Response

See attachment

Author Response File: Author Response.docx

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