Neural Signatures of Error Processing in Depressed Adolescents with Comorbid Non-Suicidal Self-Injury (NSSI)
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Psychometric Measurements
2.3. fMRI Procedure
2.4. Functional Data Acquisition
2.5. Data Analysis
2.5.1. Behavioral Data and Psychometric Measurements
2.5.2. fMRI-Data
3. Results
3.1. Demographic Data and Psychometric Measurements
3.2. fMRI Data
3.2.1. Incorrect Minus Correct Incongruent No Go Trials
3.2.2. Incorrect Minus Correct Incongruent Go Trials
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ANOVAs with Corresponding Post-Hoc Comparisons | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
HC | MD-Only | MD-NSSI | MD-NSSI vs. MD-Only | HC vs. MD-Only | HC vs. MD-NSSI | ||||||
Mean (SD) | Mean (SD) | Mean (SD) | F | p | Average Difference | pbonf | Average Difference | pbonf | Average Difference | pbonf | |
Demographics | |||||||||||
N | 14 | 13 | 14 | - | - | ||||||
Female | n = 11 | n = 10 | n = 11 | - | - | ||||||
Male | n = 3 | n = 3 | n = 3 | - | - | ||||||
age [years] | 14.4 (1.8) | 16.2 (1.4) | 15.4 (1.9) | 3.349 | 0.046 | −0.797 | 0.721 | −1.725 | 0.041 | −0.929 | 0.494 |
Psychometry | |||||||||||
IQ | 109.6 (10.6) | 101.8 (11.8) | 101.3 (13.2) | 2.093 | 0.137 | - | - | - | - | - | - |
CDRS-R score | 21.4 (2.6) | 56.4 (7.4) | 51.4 (13.6) | 59.29 | <0.001 | −4.956 | 0.498 | −34.956 | <0.001 | −30.000 | <0.001 |
BDI-II score * | 2.9 (3.6) | 27.2 (10.7) | 21.7 (12.2) | 23.988 | <0.001 | −5.452 | 0.462 | −24.31 | <0.001 | −18.857 | <0.001 |
Number of NSSI events last year | 0 | 0 | 93.3 (225.9) | - | - |
ANOVAs with Corresponding Post-Hoc Comparisons | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
HC | MD-Only | MD-NSSI | MD-NSSI vs. MD-Only | HC vs. MD-Only | HC vs. MD-NSSI | ||||||
Mean (SD) | Mean (SD) | Mean (SD) | F | p | Average Difference | pbonf | Average Difference | pbonf | Average Difference | pbonf | |
Incongruent No Go | |||||||||||
Number of commission errors | 9.6 (6.5) | 11.6 (6.9) | 18.0 (11.6) | 3.517 | 0.040 | 6.385 | 0.193 | −1.973 | 1.000 | −8.357 | 0.046 |
Reaction time [ms] | 448.5 (57.9) | 390.4 (53.8) | 457.3 (67.8) | 4.562 | 0.017 | −66.877 | 0.024 | 58.138 | 0.058 | −8.739 | 1.000 |
Incongruent Go | |||||||||||
Number of errors | 2.8 (2.0) | 3.5 (3.7) | 4.3 (4.1) | 0.686 | 0.510 | - | - | - | - | - | - |
Reaction time incorrect [ms] | 470.4 (39.4) | 393.5 (43.3) | 412.8 (47.3) | 9.883 | <0.001 | 19.259 | 0.917 | 76.88 | <0.001 | 57.621 | 0.010 |
Number of correct responses | 21.1 (11.0) | 23.3 (11.0) | 20.4 (10.3) | 0.263 | 0.771 | - | - | - | - | - | - |
Reaction time correct [ms] | 468.0 (43.0) | 410.4 (36.0) | 427.0 (46.9) | 6.685 | 0.003 | 16.614 | 0.946 | 57.643 | 0.003 | 41.029 | 0.044 |
BA | Anatomic Label | L/R/M | Cluster Size | Z | MNI | |||
---|---|---|---|---|---|---|---|---|
k (Vx) | x | y | z | |||||
MD-NSSI < MD-only | 32 | dACC | M | 183 | 3.80 | 10 | 22 | 38 |
45 | IFG, pars triangularis | L | 427 | 3.62 | −48 | 40 | 10 | |
48 | IFG, pars opercularis | L | 348 | 4.34 | −38 | 4 | 28 | |
40 | supramarginal gyrus | L | 498 | 3.13 | −64 | −34 | 30 | |
2 | inferior parietal cortex | L | # | 3.53 | −42 | −32 | 40 | |
HC < MD-only | 48 | anterior insula | L | 1238 | 4.45 | −38 | −2 | 18 |
48 | postcentral gyrus | L | # | 3.88 | −48 | −6 | 18 | |
3 | postcentral gyrus | L | # | 3.82 | −56 | −16 | 40 | |
40 | inferior parietal cortex | L | # | 3.23 | −40 | −34 | 38 | |
precuneus | L | 438 | 4.02 | −14 | −50 | 50 | ||
37 | cerebellum | L | 189 | 6.63 | −20 | −42 | −26 | |
MD-NSSI < HC | 45 | middle frontal gyrus | R | 449 | 3.62 | 44 | 34 | 24 |
48 | IFG, pars triangularis | R | # | 3.27 | 38 | 26 | 28 | |
48 | IFG, pars opercularis | R | # | 3.24 | 44 | 16 | 30 | |
48 | supramarginal gyrus | R | 366 | 3.63 | 58 | −42 | 26 | |
40 | inferior parietal cortex | L | 191 | 4.00 | −42 | −44 | 52 | |
HC < MD-NSSI | precuneus | L | 944 | 4.05 | −12 | −46 | 52 |
BA | Anatomic Label | L/R/M | Cluster Size | Z | MNI | |||
---|---|---|---|---|---|---|---|---|
k (Vx) | x | Y | z | |||||
MD-NSSI < MD-only | 45 | IFG, pars triangularis | L | 232 | 4.12 | −48 | 26 | 10 |
45 | IFG, pars triangularis | R | 199 | 3.11 | 54 | 32 | 4 | |
48 | IFG, pars opercularis | R | # | 3.53 | 50 | 14 | 6 | |
MD-only < MD-NSSI | 6 | SMA | M | 297 | 4.02 | 2 | −4 | 56 |
HC < MD-only | 45 | IFG, pars triangularis | L | 499 | 4.60 | −48 | 30 | 12 |
48 | anterior insula | L | # | 3.15 | −40 | 14 | 6 |
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Malejko, K.; Hafner, S.; Brown, R.C.; Plener, P.L.; Grön, G.; Graf, H.; Abler, B. Neural Signatures of Error Processing in Depressed Adolescents with Comorbid Non-Suicidal Self-Injury (NSSI). Biomedicines 2022, 10, 3188. https://doi.org/10.3390/biomedicines10123188
Malejko K, Hafner S, Brown RC, Plener PL, Grön G, Graf H, Abler B. Neural Signatures of Error Processing in Depressed Adolescents with Comorbid Non-Suicidal Self-Injury (NSSI). Biomedicines. 2022; 10(12):3188. https://doi.org/10.3390/biomedicines10123188
Chicago/Turabian StyleMalejko, Kathrin, Stefan Hafner, Rebecca C. Brown, Paul L. Plener, Georg Grön, Heiko Graf, and Birgit Abler. 2022. "Neural Signatures of Error Processing in Depressed Adolescents with Comorbid Non-Suicidal Self-Injury (NSSI)" Biomedicines 10, no. 12: 3188. https://doi.org/10.3390/biomedicines10123188