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Biomedicines
Volume 10
Issue 2
10.3390/biomedicines10020438
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Article

coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid–Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications

by
Felicia Roffo
1,2,
Alfonso Maria Ponsiglione
1,
Paolo Antonio Netti
1,2,3 and
Enza Torino
1,2,3,*
1
Department of Chemical, Materials and Production Engineering (DICMaPI), University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy
2
Interdisciplinary Research Center on Biomaterials, CRIB, University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy
3
Center for Advanced Biomaterials for Health Care, CABHC, Istituto Italiano di Tecnologia, IIT@CABHC, Largo Barsanti e Matteucci 53, 80125 Naples, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(2), 438; https://doi.org/10.3390/biomedicines10020438
Submission received: 14 January 2022 / Revised: 4 February 2022 / Accepted: 8 February 2022 / Published: 14 February 2022
(This article belongs to the Special Issue Theranostic Drug Delivery: Prospects and Problems)
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Abstract

An optimal design of nanocarriers is required to overcome the gap between synthetic and biological identity, improving the clinical translation of nanomedicine. A new generation of hybrid vehicles based on lipid–polymer coupling, obtained by Microfluidics, is proposed and validated for theranostics and multimodal imaging applications. A coupled Hydrodynamic Flow Focusing (cHFF) is exploited to control the time scales of solvent exchange and the coupling of the polymer nanoprecipitation with the lipid self-assembly simultaneously, guiding the formation of Lipid–Polymer NPs (LiPoNs). This hybrid lipid–polymeric tool is made up of core–shell structure, where a polymeric chitosan core is enveloped in a lipid bilayer, capable of co-encapsulating simultaneously Gd-DTPA and Irinotecan/Atto 633 compounds. As a result, a monodisperse population of hybrid NPs with an average size of 77 nm, with preserved structural integrity in different environmental conditions and high biocompatibility, can be used for MRI and Optical applications. Furthermore, preliminary results show the enhanced delivery and therapeutic efficacy of Irinotecan-loaded hybrid formulation against U87 MG cancers cells.
Keywords: microfluidics; hydrodynamic flow focusing; hybrid nanoparticle; lipid–polymer; liposome; drug delivery; theranostics; nano-bio interactions microfluidics; hydrodynamic flow focusing; hybrid nanoparticle; lipid–polymer; liposome; drug delivery; theranostics; nano-bio interactions
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MDPI and ACS Style

Roffo, F.; Ponsiglione, A.M.; Netti, P.A.; Torino, E. coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid–Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications. Biomedicines 2022, 10, 438. https://doi.org/10.3390/biomedicines10020438

AMA Style

Roffo F, Ponsiglione AM, Netti PA, Torino E. coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid–Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications. Biomedicines. 2022; 10(2):438. https://doi.org/10.3390/biomedicines10020438

Chicago/Turabian Style

Roffo, Felicia, Alfonso Maria Ponsiglione, Paolo Antonio Netti, and Enza Torino. 2022. "coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid–Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications" Biomedicines 10, no. 2: 438. https://doi.org/10.3390/biomedicines10020438

APA Style

Roffo, F., Ponsiglione, A. M., Netti, P. A., & Torino, E. (2022). coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid–Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications. Biomedicines, 10(2), 438. https://doi.org/10.3390/biomedicines10020438

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