The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
Abstract
:1. Introduction
2. The Link between Obesity and EOC
3. Biological Functions of Resistin
- the PI3K–Akt signaling pathway in chondrosarcoma cells, through downregulation of microRNA expression (miR)–16–5p [96];
- the PI3K–Akt–Sp1 pathway in ovarian cancer cells (HO-8910) through increasing the interaction with Specificity protein 1 (Sp1), triggering progressive phosphorylation of Sp1 on Thr453 and Thr739 [97];
- ERK, c-Jun N-terminal kinase (JNK), and p38 pathways activation in osteocarcinoma cells [98];
4. The Role and Significance of Resistin in the Biology and Progression of Epithelial Ovarian Cancer
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Odds Ratio (95 % CI) |
---|---|
P16INK4a | 2.657 (1.173–6.014) |
Polycystic ovarian syndrome | 1.580 (1.081–2.310) |
Endometriosis | 1.433 (1.294–1.586) |
Obesity | 1.274 (1.194–1.36) |
Hormone therapy (estrogen-progestin) | 1.190 (1.043–1.357) |
Overweight | 1.079 (1.041–1.119) |
BRCA2 N372H rs144848 | 1.079 (1.018–1.143) |
MTHFR C677T | 1.077 (1.032–1.124) |
Recreational physical activity | 0.830 (0.745–0.925) |
Oral contraceptive | 0.655 (0.515–0.833) |
Breast feeding | 0.719 (0.679–0.762) |
Differences in the Functioning of Adipose Tissue | Lean | Obese |
---|---|---|
Immune Cell Populations | ILC2s, Tregs, eosinophils, type II NKT and Th2 cells, and M2-like macrophages | Th1, NK, CD8+ T cells, adipocyte MHC II, M1-like macrophages |
Cytokines | IL-4, IL-5, IL-10, IL-13, IL-25, IL-33 | IL-1β, IL-6, TNFα, IFN-γ |
Adipokines | Adiponectin, Sfrp5 | Leptin |
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Parafiniuk, K.; Skiba, W.; Pawłowska, A.; Suszczyk, D.; Maciejczyk, A.; Wertel, I. The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer. Biomedicines 2022, 10, 920. https://doi.org/10.3390/biomedicines10040920
Parafiniuk K, Skiba W, Pawłowska A, Suszczyk D, Maciejczyk A, Wertel I. The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer. Biomedicines. 2022; 10(4):920. https://doi.org/10.3390/biomedicines10040920
Chicago/Turabian StyleParafiniuk, Klaudia, Wiktoria Skiba, Anna Pawłowska, Dorota Suszczyk, Aleksandra Maciejczyk, and Iwona Wertel. 2022. "The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer" Biomedicines 10, no. 4: 920. https://doi.org/10.3390/biomedicines10040920