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The Evolution of Blood Cell Phenotypes, Intracellular and Plasma Cytokines and Morphological Changes in Critically Ill COVID-19 Patients
 
 
Article
Peer-Review Record

Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells)

Biomedicines 2022, 10(5), 1094; https://doi.org/10.3390/biomedicines10051094
by Juan Pedro Lapuente 1,*, Gonzalo Gómez 1, Joaquín Marco-Brualla 2, Pablo Fernández 1, Paula Desportes 3, Jara Sanz 3, Mario García-Gil 4, Fernando Bermejo 5,6, Juan Víctor San Martín 7, Alicia Algaba 8, Juan Carlos De Gregorio 1, Daniel Lapuente 1, Almudena De Gregorio 1, Belén Lapuente 1, Sergio Gómez 1, María de las Viñas Andrés 1 and Alberto Anel 2,*
Reviewer 1:
Reviewer 2: Anonymous
Biomedicines 2022, 10(5), 1094; https://doi.org/10.3390/biomedicines10051094
Submission received: 4 April 2022 / Revised: 2 May 2022 / Accepted: 5 May 2022 / Published: 8 May 2022

Round 1

Reviewer 1 Report

Dear Authors,

Congratulations for great work, very interesting and time consuming work. I only found minor errors or missed the given information - I included some suggestions to explain something a bit more.

In general, my opinion is to accept with minor corrections.

Good luck!

JG 

Comments for author File: Comments.pdf

Author Response

Dear Colleague:


Thank you very much for the interest, work and time you have invested in reviewing our work. We deeply appreciate your help and comments.

Kind regards from Spain

Author Response File: Author Response.pdf

Reviewer 2 Report

This is a well written  manuscript with some interesting findings, explored about the efficacy of intravenous PRS CK STORM  drug, which can prevent and treat cytokine storms associated with infectious diseases of any type, including COVID-19. Methodology and data executions were adequate. I would like to congratulate the authors on their wonderful work.

Author Response

Dear Colleague:


Thank you very much for the interest, work and time you have invested in reviewing our work. We deeply appreciate your help and comments.

Kind regards from Spain

Author Response File: Author Response.pdf

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