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Article

CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment

by
Michele Lauriola
1,
Grazia D’Onofrio
2,*,
Annamaria la Torre
3,*,
Filomena Ciccone
2,
Carmela Germano
1,
Leandro Cascavilla
1 and
Antonio Greco
1
1
Complex Unit of Geriatrics, Department of Medical Sciences, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
2
Clinical Psychology Service, Health Department, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
3
Laboratory of Gerontology and Geriatrics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
*
Authors to whom correspondence should be addressed.
Biomedicines 2022, 10(6), 1381; https://doi.org/10.3390/biomedicines10061381
Submission received: 31 March 2022 / Revised: 1 June 2022 / Accepted: 7 June 2022 / Published: 10 June 2022
(This article belongs to the Special Issue State of the Art: Neurodegenerative Diseases in Italy)
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Abstract

Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, affective, and functional assessment scales. MTA was evaluated from 0 (no atrophy) to 4 (severe atrophy). The homocysteine serum was set to two levels: between 0 and 10 µmol/L, and >10 µmol/L. The cholesterol and glycemia blood concentrations were measured. Hypertension and atrial fibrillation presence/absence were collected. A total of 14 patients were MTA 0, 44 patients were MTA 1, 63 patients were MTA 2, 79 patients were MTA 3, and 39 patients were MTA 4. Cognitive (p < 0.0001) and functional (p < 0.0001) parameters decreased according to the MTA severity. According to the diagnosis distribution, AD patient percentages increased by MTA severity (p < 0.0001). In addition, the homocysteine levels increased according to MTA severity (p < 0.0001). Depression (p < 0.0001) and anxiety (p = 0.001) increased according to MTA severity. This study encourages and supports the potential role of MTA score and CT scan in the field of neurodegenerative disorder research and diagnosis.
Keywords: atrophy; cognitive impairment; dementia; functional status; neuropsychiatric symptoms; homocysteine level atrophy; cognitive impairment; dementia; functional status; neuropsychiatric symptoms; homocysteine level

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MDPI and ACS Style

Lauriola, M.; D’Onofrio, G.; la Torre, A.; Ciccone, F.; Germano, C.; Cascavilla, L.; Greco, A. CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment. Biomedicines 2022, 10, 1381. https://doi.org/10.3390/biomedicines10061381

AMA Style

Lauriola M, D’Onofrio G, la Torre A, Ciccone F, Germano C, Cascavilla L, Greco A. CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment. Biomedicines. 2022; 10(6):1381. https://doi.org/10.3390/biomedicines10061381

Chicago/Turabian Style

Lauriola, Michele, Grazia D’Onofrio, Annamaria la Torre, Filomena Ciccone, Carmela Germano, Leandro Cascavilla, and Antonio Greco. 2022. "CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment" Biomedicines 10, no. 6: 1381. https://doi.org/10.3390/biomedicines10061381

APA Style

Lauriola, M., D’Onofrio, G., la Torre, A., Ciccone, F., Germano, C., Cascavilla, L., & Greco, A. (2022). CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment. Biomedicines, 10(6), 1381. https://doi.org/10.3390/biomedicines10061381

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