Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2
Abstract
:1. Introduction
2. Methods
2.1. Study Design and Participants
2.2. 25OHD Levels
2.3. Antibody Response
2.4. T-Cell Response
2.5. Statistical Analysis
3. Results
3.1. 25OHD and SARS-CoV-2 Antibody Response
3.2. 25OHD and SARS-CoV-2 Specific T-Cell Response
3.3. Changes of 25OHD and Immune Response
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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GENDER | |||
Male (%) | 20 (19.8) | ||
Female (%) | 81(80.2) | ||
Median Age (IQR) | 44 (34–52) | ||
TIME POINTS | T0 | T2 (21 days; 19–44) | T3 (161 days; 110–276) |
25OHD (ng/mL) | 16.2; 11.5–22.9 | 14.55; 10.3–19.5 | 26.25; 19.65–32.8 |
Anti-Trimeric Antibody (AU/mL) | N.A | 800.0; 692–800.0 | 176.0; 119.5–301 |
Serum neutralizing titer | N.A | 320; 320–640 | 40; 20–80 |
Anti-Spike T cell response (SFC/million PBMCs) | N.A | 115; 65–205 | 40; 20–77.5 |
(Median, IQR) |
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Zelini, P.; d’Angelo, P.; Cereda, E.; Klersy, C.; Sabrina, P.; Albertini, R.; Grugnetti, G.; Grugnetti, A.M.; Marena, C.; Cutti, S.; et al. Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2. Biomedicines 2022, 10, 1993. https://doi.org/10.3390/biomedicines10081993
Zelini P, d’Angelo P, Cereda E, Klersy C, Sabrina P, Albertini R, Grugnetti G, Grugnetti AM, Marena C, Cutti S, et al. Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2. Biomedicines. 2022; 10(8):1993. https://doi.org/10.3390/biomedicines10081993
Chicago/Turabian StyleZelini, Paola, Piera d’Angelo, Emanuele Cereda, Catherine Klersy, Peressini Sabrina, Riccardo Albertini, Giuseppina Grugnetti, Anna Maria Grugnetti, Carlo Marena, Sara Cutti, and et al. 2022. "Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2" Biomedicines 10, no. 8: 1993. https://doi.org/10.3390/biomedicines10081993