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Association of Severe Bronchiolitis during Infancy with Childhood Asthma Development: An Analysis of the ECHO Consortium

Biomedicines 2023, 11(1), 23; https://doi.org/10.3390/biomedicines11010023
by Makiko Nanishi 1,*, Aruna Chandran 2, Xiuhong Li 2, Joseph B. Stanford 3, Akram N. Alshawabkeh 4, Judy L. Aschner 5, Dana Dabelea 6, Anne L. Dunlop 7, Amy J. Elliott 8, James E. Gern 9, Tina Hartert 10, Julie Herbstman 11, Gurjit K. Khurana Hershey 12, Alison E. Hipwell 13, Margaret R. Karagas 14, Catherine J. Karr 15,16,17, Leslie D. Leve 18, Augusto A. Litonjua 19, Cindy T. McEvoy 20, Rachel L. Miller 21, Emily Oken 22, T. Michael O’Shea 23, Nigel Paneth 24, Scott T. Weiss 25, Robert O. Wright 26, Rosalind J. Wright 26, Kecia N. Carroll 26, Xueying Zhang 26, Qi Zhao 27, Edward Zoratti 28, Carlos A. Camargo, Jr. 1 and Kohei Hasegawa 1 on behalf of the Environmental Influences on Child Health Outcomes (ECHO) Investigatorsadd Show full author list remove Hide full author list
Reviewer 1:
Reviewer 2: Anonymous
Biomedicines 2023, 11(1), 23; https://doi.org/10.3390/biomedicines11010023
Submission received: 21 November 2022 / Accepted: 13 December 2022 / Published: 22 December 2022

Round 1

Reviewer 1 Report

No one

Reviewer 2 Report

This study, using large nationwide pediatric cohort data—the NIH Environmental influences on Child  Health Outcomes (ECHO) Program, aimed to quantify interactions between bronchiolitis hospitalization during infancy and major demographic factors on the risk of asthma development, exploiting data on more than 11,700 children from 53 participating cohorts in US. Data are well presented and analyzed; results consolidate previous reports in the literature but also highlight  controversial issues (e,g. risk heterogeneity by subpopulations, the protective role of breast feeding) to be further investigated. Limitations are also well presented.

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