Association of Severe Bronchiolitis during Infancy with Childhood Asthma Development: An Analysis of the ECHO Consortium
Round 1
Reviewer 1 Report
No one
Reviewer 2 Report
This study, using large nationwide pediatric cohort data—the NIH Environmental influences on Child Health Outcomes (ECHO) Program, aimed to quantify interactions between bronchiolitis hospitalization during infancy and major demographic factors on the risk of asthma development, exploiting data on more than 11,700 children from 53 participating cohorts in US. Data are well presented and analyzed; results consolidate previous reports in the literature but also highlight controversial issues (e,g. risk heterogeneity by subpopulations, the protective role of breast feeding) to be further investigated. Limitations are also well presented.