A Mathematical Model for Determining the Body’s Fluctuating Need for and Synthesis of Active Vitamin D

Round 1

Reviewer 1 Report

The present paper aimed to demonstrate that serum active vitamin D levels often do not correlate with vitamin D precursor levels and may not correlate well with active vitamin D synthesis in the body.

A few changes are needed, as follows:

Please explain every abbreviation before using it, including figure legends.

Please provide some final conclusions for your manuscript!

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript titled “Determination of 1,25(OH)2D3 Synthesis and Demand, and Percent 25(OH)D3 Utilization” attempted to demonstrate a mathematical model involving active vitamin D and precursor to it.

 As such the work in this manuscript is interesting. However, there are some deficiencies in the manuscript which need to be addressed to make it publishable:

 1.      The title of the manuscript is bit confusing in the current form and can be modified to include the model.

2.      Introduction- authors highlighted the deficiency of vitamin D in COVID-19 as a prime point in the introduction. This is important that authors summarize the multitude roles of vitamin D in different conditions.

3.      Quality of the figures should be improved. The fonts and schematics are sometimes unclear.

4.      There are shorter paragraphs without developing a flow concepts. They need to be combined with concept similarity. 

5.      Potential application of this model and calculations should be highlighted in the discussion section.

Author Response

Please see the attachment

Author Response File: Author Response.docx