Next Article in Journal
Immune Response and Molecular Mechanisms of Cardiovascular Adverse Effects of Spike Proteins from SARS-CoV-2 and mRNA Vaccines
Next Article in Special Issue
Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement
Previous Article in Journal
Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis
Previous Article in Special Issue
The Emerging Role of Menstrual-Blood-Derived Stem Cells in Endometriosis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 11
Issue 2
10.3390/biomedicines11020450
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder

by
Michela Cirillo
1,2,
Flavia Rita Argento
3,
Monica Attanasio
1,
Matteo Becatti
3,
Irene Ladisa
2,
Claudia Fiorillo
3,
Maria Elisabetta Coccia
2,3 and
Cinzia Fatini
1,2,*
1
Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy
2
Centre for Assisted Reproductive Technology, Division of Obstetrics and Gynaecology, Careggi University Hospital, 50134 Florence, Italy
3
Department of Clinical and Experimental Biomedical Sciences, University of Florence, 50134 Florence, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2023, 11(2), 450; https://doi.org/10.3390/biomedicines11020450
Submission received: 20 December 2022 / Revised: 30 January 2023 / Accepted: 2 February 2023 / Published: 3 February 2023
(This article belongs to the Special Issue Advanced Research in Endometriosis 3.0)
Browse Figures
Review Reports Versions Notes

Abstract

Background: Accelerated atherosclerosis in patients with endometriosis has been hypothesised, and lifestyle improvement might control cardiovascular risk. We explored cardiometabolic markers and oxidative stress and evaluated the effects of the Mediterranean Diet (MD) in modulating these markers. Methods: In this prospective study, we included 35 women with endometriosis. At baseline (T0) and after 3 (T1) and 6 (T2) months from the start of the diet, we investigated cardiometabolic parameters, lifestyle and oxidative stress. Results: After a 3-month intervention with MD, we observed a significant reduction in total cholesterol (p = 0.01) and LDL-c (p = 0.003). We observed at T1 an increase in B12 and E vitamins, folate and zinc. After 6 months, zinc (p = 0.04) and folate (p = 0.08) increased in comparison to T0. A reduction in homocysteine from T0 to T1 (p = 0.01) was found. After 3 months, an increase in Rapid Assessment of Physical Activity tool 1 (RAPA) (p < 0.001) and RAPA 2 was observed (p = 0.009). We observed high levels of oxidative stress markers at baseline. After 6 months of MD, a significant improvement in lymphocyte Reactive Oxygen Species (ROS) (p < 0.001) and total antioxidant capacity was observed (p = 0.02). Conclusions: The improvement of lifestyle, and in particular the Mediterranean dietary intervention, allowed the improvement of the metabolic and oxidative profile and overall health-related quality of life.
Keywords: cardiovascular disease; atherosclerosis; endometriosis; Mediterranean Diet; lifestyle; risk factors; oxidative stress; gender medicine cardiovascular disease; atherosclerosis; endometriosis; Mediterranean Diet; lifestyle; risk factors; oxidative stress; gender medicine

Share and Cite

MDPI and ACS Style

Cirillo, M.; Argento, F.R.; Attanasio, M.; Becatti, M.; Ladisa, I.; Fiorillo, C.; Coccia, M.E.; Fatini, C. Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder. Biomedicines 2023, 11, 450. https://doi.org/10.3390/biomedicines11020450

AMA Style

Cirillo M, Argento FR, Attanasio M, Becatti M, Ladisa I, Fiorillo C, Coccia ME, Fatini C. Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder. Biomedicines. 2023; 11(2):450. https://doi.org/10.3390/biomedicines11020450

Chicago/Turabian Style

Cirillo, Michela, Flavia Rita Argento, Monica Attanasio, Matteo Becatti, Irene Ladisa, Claudia Fiorillo, Maria Elisabetta Coccia, and Cinzia Fatini. 2023. "Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder" Biomedicines 11, no. 2: 450. https://doi.org/10.3390/biomedicines11020450

APA Style

Cirillo, M., Argento, F. R., Attanasio, M., Becatti, M., Ladisa, I., Fiorillo, C., Coccia, M. E., & Fatini, C. (2023). Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder. Biomedicines, 11(2), 450. https://doi.org/10.3390/biomedicines11020450

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop