Next Article in Journal
Evaluation of the Antioxidant Activity of Levetiracetam in a Temporal Lobe Epilepsy Model
Next Article in Special Issue
Exploratory Evaluation of Neopterin and Chitotriosidase as Potential Circulating Biomarkers for Colorectal Cancer
Previous Article in Journal
Oral Candidiasis in Adult and Pediatric Patients with COVID-19
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 11
Issue 3
10.3390/biomedicines11030847
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Characteristic Analysis of Featured Genes Associated with Cholangiocarcinoma Progression

by
Qigu Yao
1,
Wenyi Chen
1,
Feiqiong Gao
1,
Yuchen Wu
1,
Lingling Zhou
1,
Haoying Xu
1,
Jong Yu
1,
Xinli Zhu
2,
Lan Wang
3,
Lanjuan Li
1,4 and
Hongcui Cao
1,3,*
1
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, China
2
Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, China
3
Key Laboratory of Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases of Zhejiang Province, 79 Qingchun Road, Hangzhou 310003, China
4
Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, China
*
Author to whom correspondence should be addressed.
Biomedicines 2023, 11(3), 847; https://doi.org/10.3390/biomedicines11030847
Submission received: 10 January 2023 / Revised: 28 February 2023 / Accepted: 7 March 2023 / Published: 10 March 2023
(This article belongs to the Special Issue 10th Anniversary of Biomedicines—Advances in Gastrointestinal Cancers Diagnostics and Therapeutics)
Browse Figures
Review Reports Versions Notes

Abstract

The noninvasive diagnosis of cholangiocarcinoma (CCA) is insufficiently accurate. Therefore, the discovery of new prognostic markers is vital for the understanding of the CCA mechanism and related treatment. The information on CCA patients in The Cancer Genome Atlas database was used for weighted gene co-expression network analysis. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were applied to analyze the modules of interest. By using receiver operating characteristic (ROC) analysis to analyze the Human Protein Atlas (HPA), the featured genes were subsequently verified. In addition, clinical samples and GSE119336 cohort data were also collected for the validation of these hub genes. Using WGCNA, we identified 61 hub genes that regulated the progression and prognosis of CCA. Eight hub genes (VSNL1, TH, PCP4, IGDCC3, RAD51AP2, MUC2, BUB1, and BUB1B) were identified which exhibited significant interactions with the tumorigenic mechanism and prognosis of CCA. In addition, GO and KEGG clarified that the blue and magenta modules were involved with chromosome segregation, mitotic and oocyte meiosis, the cell cycle, and sister chromatid segregation. Four hub genes (VSNL1, PCP4, BUB1, and BUB1B) were also verified as featured genes of progression and prognosis by the GSE119336 cohort data and five human tissue samples.
Keywords: cholangiocarcinoma; hub gene; tumorigenic mechanism; prognostic biomarkers; weighted gene co-expression network analysis cholangiocarcinoma; hub gene; tumorigenic mechanism; prognostic biomarkers; weighted gene co-expression network analysis

Share and Cite

MDPI and ACS Style

Yao, Q.; Chen, W.; Gao, F.; Wu, Y.; Zhou, L.; Xu, H.; Yu, J.; Zhu, X.; Wang, L.; Li, L.; et al. Characteristic Analysis of Featured Genes Associated with Cholangiocarcinoma Progression. Biomedicines 2023, 11, 847. https://doi.org/10.3390/biomedicines11030847

AMA Style

Yao Q, Chen W, Gao F, Wu Y, Zhou L, Xu H, Yu J, Zhu X, Wang L, Li L, et al. Characteristic Analysis of Featured Genes Associated with Cholangiocarcinoma Progression. Biomedicines. 2023; 11(3):847. https://doi.org/10.3390/biomedicines11030847

Chicago/Turabian Style

Yao, Qigu, Wenyi Chen, Feiqiong Gao, Yuchen Wu, Lingling Zhou, Haoying Xu, Jong Yu, Xinli Zhu, Lan Wang, Lanjuan Li, and et al. 2023. "Characteristic Analysis of Featured Genes Associated with Cholangiocarcinoma Progression" Biomedicines 11, no. 3: 847. https://doi.org/10.3390/biomedicines11030847

APA Style

Yao, Q., Chen, W., Gao, F., Wu, Y., Zhou, L., Xu, H., Yu, J., Zhu, X., Wang, L., Li, L., & Cao, H. (2023). Characteristic Analysis of Featured Genes Associated with Cholangiocarcinoma Progression. Biomedicines, 11(3), 847. https://doi.org/10.3390/biomedicines11030847

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop