HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Definitions
2.3. Samples
2.4. Flow Cytometry Staining
2.5. Flow Cytometry Calibration
2.6. Flow Cytometry Analysis
2.7. Plasma Analysis
2.8. Statistical Analysis
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Total Cohort n = 77 | Septic n = 55 | Non-Septic n = 22 | p-Value |
---|---|---|---|---|
Female sex (n. of patients, (%)) | 26 (34) | 17 (31) | 9 (41) | 0.400 |
Age (years), (IQR) | 54 ± 16 | 54 ± 16 | 56 ± 16 | 0.520 |
Basal SOFA * score (IQR) | 7 ± 4 | 8 ± 3 | 4 ± 3 | <0.001 |
APACHE ** II score (IQR) | 21 ± 7 | 22 ± 6 | 19 ± 9 | 0.050 |
Median hospital days (IQR) | 21 ± 15 | 25 ± 15 | 10 ± 7 | <0.001 |
Mechanic ventilation days (IQR) | 14 ± 13 | 17 ± 13 | 4 ± 8 | <0.001 |
Comorbidities (n. of patients, (%)) | ||||
COPD *** | 6 (8) | 4 (7) | 2 (10) | 0.790 |
Smoker | 25 (32) | 16 (29) | 9 (41) | 0.320 |
Alcoholism | 15 (19) | 9 (16) | 6 (27) | 0.270 |
Cardiopathy | 8 (10) | 6 (11) | 2 (10) | 0.810 |
Chronic kidney disease | 7 (9) | 5 (9) | 2 (10) | 1.000 |
Cirrhosis | 2 (3) | 2 (4) | 0 (0) | 0.360 |
Exitus (n.patients, (%)) | 14 (18) | 11 (20) | 3 (14) | 0.510 |
Blood culture (n. of patients, (%)) | 36 (48) | 36 (66) | NA | |
Adequate antibiotic treatment (n. of patients, (%)) | 41 (53) | 41 (75) | NA | |
Clinical suspicion sepsis days (IQR) | 4 ± 1 | 4 ± 1 | ||
Shock septic (n. of patients, (%)) | 9 (12) | 9 (16) | NA |
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Quirant-Sánchez, B.; Plans-Galván, O.; Lucas, E.; Argudo, E.; Martinez-Cáceres, E.M.; Arméstar, F. HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis. Biomedicines 2023, 11, 1836. https://doi.org/10.3390/biomedicines11071836
Quirant-Sánchez B, Plans-Galván O, Lucas E, Argudo E, Martinez-Cáceres EM, Arméstar F. HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis. Biomedicines. 2023; 11(7):1836. https://doi.org/10.3390/biomedicines11071836
Chicago/Turabian StyleQuirant-Sánchez, Bibiana, Oriol Plans-Galván, Ester Lucas, Eduard Argudo, Eva María Martinez-Cáceres, and Fernando Arméstar. 2023. "HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis" Biomedicines 11, no. 7: 1836. https://doi.org/10.3390/biomedicines11071836
APA StyleQuirant-Sánchez, B., Plans-Galván, O., Lucas, E., Argudo, E., Martinez-Cáceres, E. M., & Arméstar, F. (2023). HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis. Biomedicines, 11(7), 1836. https://doi.org/10.3390/biomedicines11071836