Evaluation of Bioactive Glass Treatment for Dentin Hypersensitivity: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Eligibility Criteria
2.2. Search Strategy
2.3. Selection Process
2.4. Data Extraction
2.5. Study Risk of Bias Assessment
3. Results
3.1. Study Selection
3.2. Studies Outcomes
3.3. Risk of Bias
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient and Population (P) | Human and Animal studies |
Intervention (I) | Application of bioactive glass materials |
Comparator or control group © | Application of placebo or desensitizing agent that did not contain bioactive glass |
Outcomes (O) | Reduction of DH |
Author & Year | Title | Number of Participants | Ages of Participants | Sensitivity Measurements | At-Home/ In- Office Application | Application Instructions | Pain Assessment Scales & Type of Stimulation | Experimental Group | Control Group | Follow-Up Period | Results |
---|---|---|---|---|---|---|---|---|---|---|---|
Amaechi et al., 2021 [27] | Clinical efficacy of nanohydroxyapatite-containing toothpaste at relieving dentin hypersensitivity: an 8 week randomized control trial | 105 | 18–80 | Evaporative stimulation followed by VAS scores ≥2 on at least one tooth | At home | Brushing 2× daily for 2 min with a soft-bristled toothbrush and rinsing with 10 mL of water for 10 s. | VAS–evaporative and thermal stimulation | 15% CSPS toothpaste (Sensodyne™ Repair & Protect with NovaMin®) | 10% nano-HAP toothpaste/15% nano-HAP toothpaste/10% nano-HAP toothpaste with 5% potassium nitrate | Baseline, two, four, six, and eight weeks | CSPS was not significantly different from 15% nano-HAP and 10% nano-HAPKN. When compared to 10% nano-HAP, CSPS reduced DH significantly more at 6 and 8 weeks. |
Arshad et al., 2021 [28] | Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial | 140 | 18–50 | Evaporative stimulation followed by Schiff scores ≥2 for at least two tooth | At home | 1 min topical application with the finger about half an inch length on dry tooth surface followed by brushing with a modified bass method. | VAS-tactile, and thermal stimulation (20/35)/Schiff–thermal stimulation (32/35) | FCPS dentifrice (BioMin F®) | 8% Pro-Argin™ dentifrice (Colgate® Sensitive Pro-Relief™)/8% strontium acetate dentifrice (Sensodyne Rapid Action™)/Placebo sodium fluoride dentifrice (Colgate® Total) | Baseline, immediately, three days, two, four, and six weeks | FCPS dentifrice is an effective long-term treatment option for DH. Dentifrices containing Pro-ArginTM, and strontium acetate are effective for immediate relief from DH pain. |
Ashwini et al., 2018 [29] | Comparative evaluation of desensitizing efficacy of dentifrice containing 5% fluoro calcium phosphosilicate versus 5% calcium sodium phosphosilicate: A randomized controlled clinical trial | 60 | 18–35 | Subjective sensitivity and thermal stimulation followed by VAS scores ≥4 on at least two tooth | At home | Brushing 2× daily for 2 min with soft bristled toothbrush and with an amount equal to about half the length of the bristle head. | VAS–typical subjective sensitivity and thermal stimulation | 5% FCPS dentifrice/5% CSPS dentifrice | Fluoride dentifrice | Baseline, immediately after scaling and root planning, 15, 30, and 60 days | The FCPS group was more effective in reducing DH, followed by CSPS. |
Bhowmik et al., 2021 [30] | Comparative evaluation of fluorinol and calcium sodium phosphosilicate-containing toothpastes in the treatment of dentin hypersensitivity | 30 | Above 18 | Thermal, tactile or sweet/sour stimulation followed by VAS scores ≥6 on at least two tooth | At home | Stillman’s method of brushing using a soft toothbrush. | VAS–evaporative, thermal, and tactile stimulation | 7.5% CSPS toothpaste (Shy-NM) | Fluorinol toothpaste (Elgydium Sensitive Toothpaste) | Baseline, two, three, four weeks | DH decreased significantly in both groups. However, fluorinol toothpaste performed better in the third and fourth weeks to tactile stimulation. |
Bala et al., 2019 [31] | Comparison of Commercially available Desensitizing Toothpastes in the Management of Dentin Hypersensitivity-A Randomized Controlled Clinical Trial | 20 | 18–70 | Evaporative stimulation followed by Schiff scores ≥2 for at least two tooth | At home | Brushing 2× daily | VAS–evaporative and tactile stimulation/Schiff–evaporative stimulation | Bioactive glass toothpaste (Sensodyne Rapid Relief Toothpaste) | Arginine toothpaste (Colgate Sensitive Pro-Relief Toothpaste) | Baseline, four weeks | Toothpastes with arginine and bioactive glass are effective in reducing DH without any statistical significance between groups. |
Maximiano et al., 2019 [32] | Nd:YAG laser and calcium sodium phosphosilicate prophylaxis paste in the treatment of dentin hypersensitivity: a double-blind randomized clinical study | 70 | 18–65 | Evaporative stimulation followed by VAS scores ≥4 on at least one tooth | In office | Applied with a rubber cup at low speed for 60 s | VAS–evaporative, tactile stimulation | 15% CSPS prophylaxis paste (NovaMin®) | Nd:YAG laser/Nupro® paste with placebo Nd:YAG laser | Baseline, five min, one and four weeks | All treatments reduced DH pain equally. |
Patel et al., 2019 [33] | A randomised clinical trial on the efficacy of 5% fluoro calcium phosphosilicate-containing novel bioactive glass toothpaste | 75 | 18–70 | Evaporative stimulation followed by VAS scores ≥5 | At home | Tooth-brushing with modified bass technique using soft-bristle toothbrush | VAS–evaporative stimulation | 5% FCPS toothpaste (BioMin-F®) | 8% arginine and calcium carbonate toothpaste (/Pro-Argin®)/Placebo toothpaste | Pre-baseline, baseline (15 days), and post-baseline (1 month) | The FCPS toothpaste was reported to be more effective than the other toothpastes in treating DH. |
Randomization Process | Deviations from Intended Interventions | Missing Outcome Data | Measurement of Outcome Data | Selection of the Reported Result | Overall Risk of Bias Judgment | |
Amaechi et al. (2021) [27] | Low risk | Some concerns | Some concerns | Low risk | Low risk | High risk |
Arshad et al. (2021) [28] | Low risk | Low risk | Some concerns | Low risk | Low risk | Some concerns |
Ashwini et al. (2018) [29] | Low risk | Low risk | Low risk | Low risk | Low risk | Low risk |
Bhowmik et al. (2021) [30] | Some concerns | Low risk | Low risk | Low risk | Low risk | Some concerns |
Bala et al. (2019) [31] | Some concerns | Low risk | Low risk | Some concerns | Low risk | High risk |
Maximiano et al. (2019) [32] | Low risk | Low risk | Low risk | Low risk | Low risk | Low risk |
Patel et al. (2019) [33] | Some concerns | Low risk | High risk | Low risk | Low risk | High risk |
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Petrović, D.; Galić, D.; Seifert, D.; Lešić, N.; Smolić, M. Evaluation of Bioactive Glass Treatment for Dentin Hypersensitivity: A Systematic Review. Biomedicines 2023, 11, 1992. https://doi.org/10.3390/biomedicines11071992
Petrović D, Galić D, Seifert D, Lešić N, Smolić M. Evaluation of Bioactive Glass Treatment for Dentin Hypersensitivity: A Systematic Review. Biomedicines. 2023; 11(7):1992. https://doi.org/10.3390/biomedicines11071992
Chicago/Turabian StylePetrović, Dorotea, Dora Galić, Davor Seifert, Nikolina Lešić, and Martina Smolić. 2023. "Evaluation of Bioactive Glass Treatment for Dentin Hypersensitivity: A Systematic Review" Biomedicines 11, no. 7: 1992. https://doi.org/10.3390/biomedicines11071992