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Biomedicines
Volume 11
Issue 8
10.3390/biomedicines11082188
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Article
Peer-Review Record

Mutual Effect Modification between Insulin Resistance and Endothelial Dysfunction in Predicting Incident Heart Failure in Hypertensives

Biomedicines 2023, 11(8), 2188; https://doi.org/10.3390/biomedicines11082188
by Maria Perticone 1,*,†, Raffaele Maio 2,†, Simona Gigliotti 3, Ermal Shehaj 4, Alfredo Francesco Toscani 1, Antonella Capomolla 5, Ginevra Fabiani 6, Angela Sciacqua 1 and Francesco Perticone 1
Reviewer 1:
Mariana Floria
Reviewer 2:
Jien Jiun Chen
Biomedicines 2023, 11(8), 2188; https://doi.org/10.3390/biomedicines11082188
Submission received: 13 July 2023 / Revised: 26 July 2023 / Accepted: 2 August 2023 / Published: 3 August 2023
(This article belongs to the Special Issue Aging, Inflammaging and Multimorbidity: What Is the Role of Endothelial Dysfunction?)

Round 1

Reviewer 1 Report

The manuscript entitled Mutual effect modification between insulin-resistance and endothelial dysfunction in predicting incident heart failure in hypertensives is an original paper, which investigated whether endothelial dysfunction and insulin-resistance are independent predictors of incident heart failure. The authors demonstrated, for the first time, a possible competitive interaction between maximal ACh-stimulated forearm blood flow and HOMA in the appearance of incident heart failure.

This manuscript is well written. Material and methods are well explained. The results are clearly presented. Discussions are centered on data published, which explain the results. Limitations study are appropriately.

However, I consider that ICD-10 classification for incident heart failure diagnosis could be the main issue of this study. Because the population analyzed is those with incident heart failure this could be very well defined (not by a code used by different physicians).

Author Response

We are very grateful to the Reviewer for both positive comments about our manuscript and valuable suggestions which contributed to improve the quality of our paper.

We agree with the Reviewer that ICD-10 classification for incident heart failure could be confusing. Thus, we deleted the period "and, for hospitalized patients, International Classification of Diseases, Tenth Revision (ICD-10) codes as any diagnosis: heart failure (I50), cardiomyopathies (I42.0, I42.6, I42.8, and I42.9), hypertension-induced heart disease (I11.0, I13.0, and I13.2)", and for the definition of incident heart failure we only based on ESC guidelines.

Reviewer 2 Report

the authors investigated the association of insulin resistance and endothelial dysfunction and incidence of heart failure. The study was well designed and the patients were followed for very long period. The results was rather solid that merits publication. 

The English was fine 

Author Response

We thank the Reviewer for the valuable positive comments on our manuscript.

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