Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

Kabbani, Noura; Stepan, Holger; Blüher, Matthias; Ebert, Thomas; Baber, Ronny; Vogel, Mandy; Kiess, Wieland; Stumvoll, Michael; Breitfeld, Jana; Lössner, Ulrike; Tönjes, Anke; Schrey-Petersen, Susanne

doi:10.3390/biomedicines11082220

Open AccessArticle

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

by

Noura Kabbani

^1,*

,

Holger Stepan

¹,

Matthias Blüher

^2,3

,

Thomas Ebert

²

,

Ronny Baber

^4,5,

Mandy Vogel

^6,7

,

Wieland Kiess

^6,7,

Michael Stumvoll

²,

Jana Breitfeld

²,

Ulrike Lössner

²,

Anke Tönjes

^2,† and

Susanne Schrey-Petersen

^1,*,†

¹

Department of Obstetrics, University of Leipzig Medical Center, 04103 Leipzig, Germany

²

Medical Department III—Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany

³

Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, The University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany

⁴

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig Medical Center, 04103 Leipzig, Germany

⁵

Leipzig Medical Biobank, University of Leipzig, 04103 Leipzig, Germany

⁶

LIFE Child, Hospital for Children and Adolescents, Department of Pediatrics, University of Leipzig Medical Center, 04103 Leipzig, Germany

⁷

Center for Pediatric Research (CPL), Hospital for Children and Adolescents, University of Leipzig Medical Center, 04103 Leipzig, Germany

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Biomedicines 2023, 11(8), 2220; https://doi.org/10.3390/biomedicines11082220

Submission received: 14 July 2023 / Revised: 1 August 2023 / Accepted: 2 August 2023 / Published: 8 August 2023

(This article belongs to the Special Issue 10th Anniversary of Biomedicines—Recent Advances on Adipokines)

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Abstract

Transforming growth factor beta-1 (TGFβ1) is an adipokine secreted from adipose tissue, placental tissue and immune cells with a role in cell proliferation, cell apoptosis and angiogenic proliferation. The role of TGFβ1 in pregnancy and child growth and the source of cord TGFβ1 are yet unknown. In this study, we sought to clarify the correlation of TGFβ1 levels with parameters of intrauterine growth and child growth during the first year of life, and to determine whether their source is primarily of fetal or maternal origin. Serum samples and anthropometric measurements were obtained from the LIFE Child cohort of 79 healthy mother–child pairs. Measurements were conducted using enzyme-linked immunosorbent assays. Statistical analyses including Mann–Whitney U-test, correlation analyses and linear regression analyses were performed using GraphPad Prism and R. TGFβ1 levels were significantly higher in cord than in maternal serum, suggesting a fetal origin. Multivariate regression analyses revealed strong positive associations between cord TGFβ1 levels at birth and child weight at U6. Furthermore, cord TGFβ1 was significantly correlated with child weight at approximately one year of age. An increase of 10,000 pg/mL in cord TGFβ1 concentrations at birth was associated with a higher body weight of 201 g at roughly one year of age when adjusted for sex.

Keywords: adipokine; TFGβ1; child growth; intrauterine growth; gestation

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MDPI and ACS Style

Kabbani, N.; Stepan, H.; Blüher, M.; Ebert, T.; Baber, R.; Vogel, M.; Kiess, W.; Stumvoll, M.; Breitfeld, J.; Lössner, U.; et al. Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life. Biomedicines 2023, 11, 2220. https://doi.org/10.3390/biomedicines11082220

AMA Style

Kabbani N, Stepan H, Blüher M, Ebert T, Baber R, Vogel M, Kiess W, Stumvoll M, Breitfeld J, Lössner U, et al. Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life. Biomedicines. 2023; 11(8):2220. https://doi.org/10.3390/biomedicines11082220

Chicago/Turabian Style

Kabbani, Noura, Holger Stepan, Matthias Blüher, Thomas Ebert, Ronny Baber, Mandy Vogel, Wieland Kiess, Michael Stumvoll, Jana Breitfeld, Ulrike Lössner, and et al. 2023. "Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life" Biomedicines 11, no. 8: 2220. https://doi.org/10.3390/biomedicines11082220

APA Style

Kabbani, N., Stepan, H., Blüher, M., Ebert, T., Baber, R., Vogel, M., Kiess, W., Stumvoll, M., Breitfeld, J., Lössner, U., Tönjes, A., & Schrey-Petersen, S. (2023). Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life. Biomedicines, 11(8), 2220. https://doi.org/10.3390/biomedicines11082220

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Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

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