Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy
Abstract
:1. Introduction
2. Boosting Cancer Immunotherapy with Exercise
2.1. The General Benefits of Exercise on the Immune System and in the Oncology Setting
2.2. Increased Immune Cell Trafficking, Endothelial Stabilization, and Therapy Sensitization
2.3. Positive Modulation of Immune Metabolism
2.4. Systemic Action of Exercise That Benefits Immune Fitness
2.5. The Sometimes Contradictory Evidence of In Vivo Studies
3. Discussion
4. Conclusions and Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Immunotherapy | |
| [24,25,26,27,28,29,30,42] |
| [28,29,30,43] |
Exercise | |
Enhance leukocyte metabolism and activity | [40,44,45,46,47,48,49] |
Increase overall quality of life | [11,12,13,50] |
Modulate tumor vessel blood flow | [51,52,53,54,55,56,57,58] |
Induce hyperthermia with vessel expansion and tumor growth reduction | [59,60] |
Induce release of polarizing cytokines (IL-6, IL-15) | [51,61,62,63,64,65,66,67,68,69] |
Mitigate side effects of cancer treatments | [17] |
Mobilize immune cells from lymphoid tissues to cancer sites | [70,71,72,73,74,75] |
Mobilize immune cells via adrenergic and epinephrine signaling | [59,68,69,76,77,78,79] |
Reduce intratumoral lactate | [40,80,81,82,83] |
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Casciano, F.; Caruso, L.; Zauli, E.; Gonelli, A.; Zauli, G.; Vaccarezza, M. Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. Biomedicines 2024, 12, 2528. https://doi.org/10.3390/biomedicines12112528
Casciano F, Caruso L, Zauli E, Gonelli A, Zauli G, Vaccarezza M. Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. Biomedicines. 2024; 12(11):2528. https://doi.org/10.3390/biomedicines12112528
Chicago/Turabian StyleCasciano, Fabio, Lorenzo Caruso, Enrico Zauli, Arianna Gonelli, Giorgio Zauli, and Mauro Vaccarezza. 2024. "Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy" Biomedicines 12, no. 11: 2528. https://doi.org/10.3390/biomedicines12112528