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Volume 12
Issue 3
10.3390/biomedicines12030512
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Background:
Case Report

Daratumumab and Nelarabine Treatment as Salvage Therapy for T-Lymphoblastic Lymphoma: A Case Report

by
Gonzalo Castellanos
1,†,
Laura Pardo
1,*,†,
Alberto López
1,
Javier Cornago
1,
Jose Luis López
1,
Alicia de las Heras
1,
Francisco J. Díaz
2,
Marta Martínez de Bourio
3,
Eva Castillo
4,
Pilar Llamas
1 and
Laura Solán
1
1
Department of Hematology, Fundación Jiménez Díaz University Hospital, Avenida Reyes Católicos, 28040 Madrid, Spain
2
Department of Anatomical Pathology, Fundación Jiménez Díaz University Hospital, Avenida Reyes Católicos, 28040 Madrid, Spain
3
Department of Nuclear Medicine, Fundación Jiménez Díaz University Hospital, Avenida Reyes Católicos, 28040 Madrid, Spain
4
Department of Hospital Pharmacy, Fundación Jiménez Díaz University Hospital, Avenida Reyes Católicos, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomedicines 2024, 12(3), 512; https://doi.org/10.3390/biomedicines12030512
Submission received: 25 January 2024 / Revised: 17 February 2024 / Accepted: 19 February 2024 / Published: 24 February 2024
(This article belongs to the Section Cancer Biology and Oncology)
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Abstract

T-cell lymphoblastic lymphoma is an uncommon lymphoid neoplasm in adults, although more frequent in children and teenagers, that often affects the mediastinum and bone marrow, requiring intensive chemotherapy protocols. Its prognosis is poor if a cure is not achieved with first-line treatments. We present a case report of a 19-year-old man diagnosed with this type of lymphoma due to significant respiratory distress and a mediastinal mass. He received treatment according to the hyper-CVAD regimen, with a complete metabolic response. However, seven months later a new mediastinal growth was observed, leading to salvage treatment with a combination of nelarabine and daratumumab. We observed not only refractoriness, but also leukemization, which prompted consideration of hematopoietic stem cell transplantation. Based on this case, we conducted a review of pharmacological treatment options for refractory or relapsed lymphoblastic lymphoma, as well as the role of radiotherapy in managing mediastinal disease. This case report highlights the limited evidence available regarding later-line treatments, with unusual reports regarding employing our combination of daratumumab and nelarabine, and emphasizes the importance of achieving cures in the first line of treatment.
Keywords: lymphoblastic lymphoma; relapse; salvage therapy; nelarabine; daratumumab lymphoblastic lymphoma; relapse; salvage therapy; nelarabine; daratumumab

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MDPI and ACS Style

Castellanos, G.; Pardo, L.; López, A.; Cornago, J.; López, J.L.; de las Heras, A.; Díaz, F.J.; Martínez de Bourio, M.; Castillo, E.; Llamas, P.; et al. Daratumumab and Nelarabine Treatment as Salvage Therapy for T-Lymphoblastic Lymphoma: A Case Report. Biomedicines 2024, 12, 512. https://doi.org/10.3390/biomedicines12030512

AMA Style

Castellanos G, Pardo L, López A, Cornago J, López JL, de las Heras A, Díaz FJ, Martínez de Bourio M, Castillo E, Llamas P, et al. Daratumumab and Nelarabine Treatment as Salvage Therapy for T-Lymphoblastic Lymphoma: A Case Report. Biomedicines. 2024; 12(3):512. https://doi.org/10.3390/biomedicines12030512

Chicago/Turabian Style

Castellanos, Gonzalo, Laura Pardo, Alberto López, Javier Cornago, Jose Luis López, Alicia de las Heras, Francisco J. Díaz, Marta Martínez de Bourio, Eva Castillo, Pilar Llamas, and et al. 2024. "Daratumumab and Nelarabine Treatment as Salvage Therapy for T-Lymphoblastic Lymphoma: A Case Report" Biomedicines 12, no. 3: 512. https://doi.org/10.3390/biomedicines12030512

APA Style

Castellanos, G., Pardo, L., López, A., Cornago, J., López, J. L., de las Heras, A., Díaz, F. J., Martínez de Bourio, M., Castillo, E., Llamas, P., & Solán, L. (2024). Daratumumab and Nelarabine Treatment as Salvage Therapy for T-Lymphoblastic Lymphoma: A Case Report. Biomedicines, 12(3), 512. https://doi.org/10.3390/biomedicines12030512

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