Exposure to Volatile Organic Compounds May Contribute to Atopic Dermatitis in Adults
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Determination of Clinical Parameters
2.3. Determination of Urine VOC Metabolites
2.4. Isolation of Bone Marrow-Derived Mast Cells (BMMCs)
2.5. Cell Viability
2.6. The Effect of 1,3-Butadiene and Toluene on Mast Cell Degranulation
2.7. Statistical Analyses
3. Results
3.1. Baseline Characteristics of Adult AD Patients and HCs
3.2. Urine Levels of VOC Metabolites in Adult AD Patients and HCs
3.3. Multivariate Linear Regression
3.4. Correlational Analyses
3.5. 1,3-Butadiene and Toluene Could Stimulate Mast Cell Degranulation
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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AD Patients (n = 31) | HCs (n = 11) | |
---|---|---|
Age, median (IQR) | 36 (28, 43) | 24 (20, 34) |
Female | 13 (42%) | 7 (64%) |
Allergic rhinitis | 14 (45%) | 0 (0%) |
Asthma | 8 (26%) | 0 (0%) |
Smoking | 7 (23%) | 2 (18%) |
Serum total IgE (IU/mL) | 610 (181, 5000) | NA |
SCORAD index | 30.2 (12.8, 52.9) | NA |
Systemic medications | ||
Antihistamine | 28 (90%) | NA |
Oral corticosteroids | 16 (52%) | NA |
Azathioprine | 4 (13%) | NA |
Cyclosporine | 3 (10%) | NA |
Methotrexate | 10 (32%) | NA |
Omalizumab | 3 (10%) | NA |
Coefficients (95% CI ‡) | AAMA | BMA | DHBMA | GAMA |
---|---|---|---|---|
Age | 0.007 (−0.022, 0.035) | 0.014 (−0.030, 0.059) | 0.002 (−0.016, 0.021) | 0.015 (−0.023, 0.053) |
Male sex | 0.037 (−0.508, 0.583) | −0.118 (−0.942, 0.705) | −0.017 (−0.339, 0.306) | −0.095 (−0.925, 0.736) |
AD patients § | −0.035 (−0.721, 0.651) | 1.100 (0.041, 2.158) | 0.364 (0.003, 0.725) | 0.900 (−0.175, 1.974) |
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Tang, K.-T.; Chen, Y.-S.; Lee, M.-F.; Chen, T.-T.; Lai, C.-C.; Lin, C.-C.; Chen, Y.-H. Exposure to Volatile Organic Compounds May Contribute to Atopic Dermatitis in Adults. Biomedicines 2024, 12, 1419. https://doi.org/10.3390/biomedicines12071419
Tang K-T, Chen Y-S, Lee M-F, Chen T-T, Lai C-C, Lin C-C, Chen Y-H. Exposure to Volatile Organic Compounds May Contribute to Atopic Dermatitis in Adults. Biomedicines. 2024; 12(7):1419. https://doi.org/10.3390/biomedicines12071419
Chicago/Turabian StyleTang, Kuo-Tung, Yu-Sin Chen, Mey-Fann Lee, Tzu-Ting Chen, Chien-Chen Lai, Chi-Chien Lin, and Yi-Hsing Chen. 2024. "Exposure to Volatile Organic Compounds May Contribute to Atopic Dermatitis in Adults" Biomedicines 12, no. 7: 1419. https://doi.org/10.3390/biomedicines12071419