Next Article in Journal
Molecular Changes in the Ischemic Brain as Non-Invasive Brain Stimulation Targets—TMS and tDCS Mechanisms, Therapeutic Challenges, and Combination Therapies
Previous Article in Journal
Amantadine for Traumatic Brain Injury—Supporting Evidence and Mode of Action
Previous Article in Special Issue
Behavioral Effects of the Mixture and the Single Compounds Carbendazim, Fipronil, and Sulfentrazone on Zebrafish (Danio rerio) Larvae
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Embryonic Zebrafish as a Model for Investigating the Interaction between Environmental Pollutants and Neurodegenerative Disorders

Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(7), 1559; https://doi.org/10.3390/biomedicines12071559
Submission received: 10 June 2024 / Revised: 8 July 2024 / Accepted: 11 July 2024 / Published: 13 July 2024
(This article belongs to the Special Issue Zebrafish Models for Development and Disease 4.0)

Abstract

Environmental pollutants have been linked to neurotoxicity and are proposed to contribute to neurodegenerative disorders. The zebrafish model provides a high-throughput platform for large-scale chemical screening and toxicity assessment and is widely accepted as an important animal model for the investigation of neurodegenerative disorders. Although recent studies explore the roles of environmental pollutants in neurodegenerative disorders in zebrafish models, current knowledge of the mechanisms of environmentally induced neurodegenerative disorders is relatively complex and overlapping. This review primarily discusses utilizing embryonic zebrafish as the model to investigate environmental pollutants-related neurodegenerative disease. We also review current applicable approaches and important biomarkers to unravel the underlying mechanism of environmentally related neurodegenerative disorders. We found embryonic zebrafish to be a powerful tool that provides a platform for evaluating neurotoxicity triggered by environmentally relevant concentrations of neurotoxic compounds. Additionally, using variable approaches to assess neurotoxicity in the embryonic zebrafish allows researchers to have insights into the complex interaction between environmental pollutants and neurodegenerative disorders and, ultimately, an understanding of the underlying mechanisms related to environmental toxicants.
Keywords: apoptosis; early life exposure; environmental pollutants; neurodegenerative disorders; neurotransmission; neurotoxicity; oxidative stress; zebrafish apoptosis; early life exposure; environmental pollutants; neurodegenerative disorders; neurotransmission; neurotoxicity; oxidative stress; zebrafish

Share and Cite

MDPI and ACS Style

Yin, J.-H.; Horzmann, K.A. Embryonic Zebrafish as a Model for Investigating the Interaction between Environmental Pollutants and Neurodegenerative Disorders. Biomedicines 2024, 12, 1559. https://doi.org/10.3390/biomedicines12071559

AMA Style

Yin J-H, Horzmann KA. Embryonic Zebrafish as a Model for Investigating the Interaction between Environmental Pollutants and Neurodegenerative Disorders. Biomedicines. 2024; 12(7):1559. https://doi.org/10.3390/biomedicines12071559

Chicago/Turabian Style

Yin, Ji-Hang, and Katharine A. Horzmann. 2024. "Embryonic Zebrafish as a Model for Investigating the Interaction between Environmental Pollutants and Neurodegenerative Disorders" Biomedicines 12, no. 7: 1559. https://doi.org/10.3390/biomedicines12071559

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop