The Characteristics and Two-Year Neurodevelopmental Outcomes of Home Oxygen Therapy among Preterm Infants with Bronchopulmonary Dysplasia: A Retrospective Study in a Medical Center in Taiwan
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Patients
2.2. Clinical Variables
2.3. Outcomes
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total (n = 134) | Room Air (n = 95) | HOT (n = 39) | p Value | |
---|---|---|---|---|
Maternal Characteristics | ||||
Cesearean section, n (%) | 95 (71) | 70 (74) | 25 (64) | 0.267 |
GDM, n (%) | 12 (9) | 11 (12) | 1 (3) | 0.097 |
Oligohydraminos, n (%) | 4 (3) | 4 (4) | 0 | 0.193 |
Polyhydraminos, n (%) | 5 (4) | 4 (4) | 1 (3) | 0.648 |
Pre-eclampsia, n (%) | 22 (16) | 19 (20) | 3 (8) | 0.081 |
Chorioamnionitis, n (%) | 28 (21) | 19 (20) | 9 (23) | 0.691 |
PPROM, n (%) | 66 (49) | 45 (47) | 21 (54) | 0.496 |
Total (n = 134) | Room Air (n = 95) | HOT (n = 39) | p Value | |
---|---|---|---|---|
Neonatal Characteristics | ||||
Male, n (%) | 74 (55) | 52 (55) | 22 (56) | 0.86 |
GA (week), mean ± SD | 28 ± 2 | 29 ± 2 | 26 ± 2 | <0.001 * |
BW (gram), mean ± SD | 997 ± 284 | 1062 ± 274 | 842 ± 283 | <0.001 * |
SGA, n (%) | 18 (13) | 14 (15) | 4 (10) | 0.490 |
EOS, n (%) | 11 (8) | 5 (5) | 6 (15) | 0.053 |
LOS, n (%) | 43 (32) | 26 (27) | 17 (44) | 0.068 |
hsPDA, n (%) | 62 (46) | 37 (39) | 25 (64) | 0.005 * |
PDA ligation, n (%) | 41 (31) | 22 (23) | 19 (49) | 0.004 * |
HFOV, n (%) | 50 (37) | 26 (27) | 24 (62) | <0.001 * |
iNO, n (%) | 16 (12) | 4 (4) | 12 (31) | <0.001 * |
NEC, n (%) | 21 (16) | 16 (17) | 5 (13) | 0.561 |
IVH, n (%) | 32 (24) | 20 (21) | 12 (31) | 0.231 |
ROP, n (%) | 54 (40) | 29 (31) | 25 (64) | <0.001 * |
Pulmonary hypertension, n (%) | 9 (7) | 3 (3) | 6 (15) | 0.01 * |
Duration of invasive ventilation (day), mean ± SD | 35 ± 32 | 24 ± 26 | 60 ± 32 | <0.001 * |
Duration of oxygen support at NICU (day), mean ± SD | 87 ± 42 | 73 ± 30 | 123 ± 46 | <0.001 * |
Clinical outcome | ||||
Hospitalization (day), mean ± SD | 133 ± 40 | 87 ± 30 | 125 ± 47 | <0.001 * |
Re-hospitalization within 1 year old, n (%) | 14 (10.4) | 5 (5.3) | 9 (23.1) | 0.007 * |
Re-hospitalized for cyanosis, n (%) | 8 (6) | 1 (1.1) | 7 (17.9) | <0.001 * |
Re-hospitalized for respiratory disease, n (%) | 14 (10.4) | 6 (6.3) | 8 (20.5) | 0.013 * |
ICU admission within 1 year old, n (%) | 5 (3.7) | 2 (2.1) | 3 (7.7) | 0.116 |
ER visit within 1 year old, n (%) | 20 (14.9) | 8 (8.4) | 12 (30.8) | <0.001 * |
Room Air (n = 81) | HOT (n = 33) | p Value | |
---|---|---|---|
Cognitive score | |||
Mild delay ≥ 70 and <85, n (%) | 16/81 (19.8) | 7/33 (21.2) | 0.86 |
Moderate to severe delay < 70, n (%) | 3/81 (3.7) | 6/33 (18.2) | 0.009 * |
Language score | |||
Mild delay ≥ 70 and <85, n (%) | 32/81 (39.5) | 11/33 (33.3) | 0.537 |
Moderate to severe delay < 70, n (%) | 5/81 (6.1) | 8/33 (24.2) | 0.006 * |
Motor score | |||
Mild delay ≥ 70 and <85, n (%) | 14/81 (17.3) | 10/33 (30.3) | 0.122 |
Moderate to severe delay < 70, n (%) | 4/81 (4.9) | 4/33 (12.1) | 0.173 |
Clinical Characteristics | Odds Ratio | 95%CI | p Value |
---|---|---|---|
Gestational age | 0.760 | 0.582–0.992 | 0.044 * |
Birth weight | 0.723 | 0.997–1.002 | 0.723 |
PDA ligation | 0.764 | 0.267–2.189 | 0.616 |
Days of invasive ventilation | 1.032 | 1.012–1.052 | 0.001 * |
Duration of hospital stays | 1.002 | 0.984–1.020 | 0.806 |
Bayley III Performance Score | Our Cohort | MSCE Study (2019) # | ||||
---|---|---|---|---|---|---|
Room Air | HOT | p Value | Room Air | HOT | p Value | |
Cognitive score | ||||||
Moderate to severe delay < 70, n (%) | 3/81 (3.7) | 6/33 (18.2) | 0.009 * | 112/992 (11) | 122/973 (13) | 0.08 |
Language score | ||||||
Moderate to severe delay < 70, n (%) | 5/81 (6.1) | 8/33 (24.2) | 0.006 * | 212/960 (22) | 210/973 (22) | 0.48 |
Motor score | ||||||
Moderate to severe delay < 70, n (%) | 4/81 (4.9) | 4/33 (12.1) | 0.173 | 107/764 (14) | 107/74 (16) | 0.61 |
Characteristics | ||||||
Duration of invasive ventilation (day), mean ± SD | 24 ± 26 | 60 ± 32 | <0.001 * | 63 ± 25 | 61 ± 23 | |
Hospitalization (day), mean ± SD | 87 ± 30 | 125 ± 47 | <0.001 * | 124 ± 34 | 120 ± 40 |
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Chang, H.-P.; Lee, E.-P.; Chiang, M.-C. The Characteristics and Two-Year Neurodevelopmental Outcomes of Home Oxygen Therapy among Preterm Infants with Bronchopulmonary Dysplasia: A Retrospective Study in a Medical Center in Taiwan. Biomedicines 2024, 12, 1564. https://doi.org/10.3390/biomedicines12071564
Chang H-P, Lee E-P, Chiang M-C. The Characteristics and Two-Year Neurodevelopmental Outcomes of Home Oxygen Therapy among Preterm Infants with Bronchopulmonary Dysplasia: A Retrospective Study in a Medical Center in Taiwan. Biomedicines. 2024; 12(7):1564. https://doi.org/10.3390/biomedicines12071564
Chicago/Turabian StyleChang, Han-Pi, En-Pei Lee, and Ming-Chou Chiang. 2024. "The Characteristics and Two-Year Neurodevelopmental Outcomes of Home Oxygen Therapy among Preterm Infants with Bronchopulmonary Dysplasia: A Retrospective Study in a Medical Center in Taiwan" Biomedicines 12, no. 7: 1564. https://doi.org/10.3390/biomedicines12071564