Sex-Specific Associations between Thyroid Status, Inflammation and Hemostasis Biomarkers in Patients with Subacute Thyroiditis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Laboratory Methods
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | All (N = 52) | Men (N = 12) | Women (N = 40) | Pgender |
---|---|---|---|---|
Neutrophils, ×109/L * | 5.9 (5.1–6.6) | 6.2 (4.0–8.4) | 5.8 (5.0–6.7) | 0.487 |
Lymphocytes, ×109/L * | 2.0 (1.8–2.2) | 2.3 (1.8–2.7) | 1.9 (1.8–2.1) | 0.441 |
Monocytes, ×109/L * | 0.66 (0.57–0.83) | 0.86 (0.48–1.24) | 0.67 (0.60–0.74) | 0.025 |
Platelets, ×109/L * | 354 (312–472) | 386 (263–509) | 394 (354–434) | 0.753 |
PT, s | 13.2 (12.5–13.8) | 13.9 (12.1–15.8) | 13.2 (12.5–13.7) | 0.794 |
INR | 1.0 (0.9–1.1) | 1.0 (0.9–1.1) | 1.0 (0.9–1.1) | 0.328 |
aPTT, s * | 28.7 (27.6–29.7) | 28.7 (24.7–32.9) | 28.6 (27.6–29.7) | 0.558 |
Glucose, mmol/L | 5.4 (4.7–6.1) | 4.2 (4.1–4.8) | 5.6 (4.7–6.1) | 0.891 |
HDL-C, mmol/L | 1.16 (0.91–1.24) | 0.91 (0.85–0.93) | 1.16 (0.96–1.34) | 0.139 |
TG, mmol/L * | 1.33 (0.88–1.65) | 0.98 (0.55–1.4) | 1.36 (1.04–1.83) | 0.091 |
TSH, mIU/L | 0.008 (0.008–0.010) | 0.008 (0.008–0.008) | 0.008 (0.008–0.115) | 0.435 |
fT4, pmol/L * | 27.0 (19.3–30.9) | 33.5 (16.7–50.2) | 25.7 (18.0–29.6) | 0.178 |
Parameter | All (N = 52) | Men (N = 12) | Women (N = 40) | Pgender |
---|---|---|---|---|
CRP, mg/L * | 60 (32–91) | 70.5 (26.9–114) | 60 (32.5–85) | 0.712 |
ESR, mm/h * | 45 (30–67) | 45 (25–65) | 49 (31–71) | 0.450 |
SII * | 1190 (1016–1363) | 1033 (695–1372) | 1223 (1120–1425) | 0.529 |
NLR | 3.0 (2.6–3.4) | 2.2 (2.1–2.4) | 2.9 (2.4–3.4) | 0.617 |
TLR * | 205 (189–228) | 175 (103–247) | 211 (187–236) | 0.257 |
LMR | 2.76 (2.26–3.92) | 2.91 (1.90–3.93) | 2.76 (2.25–3.59) | 0.241 |
GLR * | 2.9 (2.6–3.2) | 2.4 (1.6–3.2) | 3.0 (2.7–3.3) | 0.298 |
CLR * | 28 (17–44) | 30.5 (11.4–49.6) | 28 (17.5–43.5) | 0.983 |
Monocytes/HDL-C * | 0.016 (0.012–0.020) | 0.023 (0.010–0.037) | 0.015 (0.012–0.019) | 0.050 |
ESR/Lymphocytes | 22 (16–33) | 13.5 (12–16.5) | 25 (17–33) | 0.190 |
fT4, pmol/L | TSH, mUI/L | |||
---|---|---|---|---|
Parameter | r | p | r | p |
CRP, mg/L | 0.380 | <0.01 | −0.372 | <0.01 |
SII | 0.333 | <0.05 | −0.128 | 0.367 |
NLR | 0.313 | <0.05 | −0.086 | 0.546 |
LMR | −0.351 | <0.05 | 0.284 | <0.05 |
CLR | 0.417 | <0.01 | −0.372 | <0.01 |
Monocytes/HDL-C | 0.317 | <0.05 | −0.411 | <0.01 |
Parameter | Sex | PT, s | aPTT, s | INR | Platelets, ×109/L |
---|---|---|---|---|---|
TSH, mUI/L | Men | −0.452 | −0.524 | −0.604 * | 0.059 |
Women | 0.036 | 0.117 | 0.084 | −0.210 | |
fT4,pmol/L | Men | −0.119 | 0.627 * | 0.238 | 0.028 |
Women | −0.109 | −0.018 | −0.209 | 0.269 | |
ESR, mm/h | Men | −0.446 | −0.114 | −0.455 | 0.745 ** |
Women | −0.171 | −0.184 | −0.214 | 0.182 | |
Neutrophils, ×109/L | Men | −0.070 | −0.140 | 0.112 | 0.315 |
Women | 0,326 * | 0.086 | 0.288 | 0.438 ** | |
Lymphocytes, ×109/L | Men | 0.277 | 0.070 | 0.266 | 0.119 |
Women | 0.005 | −0.108 | −0.089 | 0.084 | |
Monocytes, ×109/L | Men | 0.011 | −0.135 | 0.277 | 0.337 |
Women | 0.256 | −0.064 | 0.259 | 0.514 ** | |
CRP, mg/L | Men | 0.249 | 0.231 | 0.559 | 0.336 |
Women | −0.294 | 0.055 | −0.243 | 0.317 * | |
SII | Men | −0.175 | −0.392 | 0.056 | 0.741 ** |
Women | 0.382 * | 0.063 | 0.397 * | 0.696 ** | |
NLR | Men | −0.112 | −0.600 * | −0.102 | −0.032 |
Women | 0.347 * | 0.151 | 0.393 * | 0.347 * |
Factors | Variables Included in the Factor | Loadings of the Variables | Factor Variability, % (Total Variance: 46%) |
---|---|---|---|
Proinflammatory factor | Anti-inflammatory therapy | 0.702 | 19 |
CRP, mg/L | 0.687 | ||
Platelets, ×109/L | 0.645 | ||
Neutrophils, ×109/L | 0.622 | ||
Monocytes, ×109/L | 0.619 | ||
ESR, mm/h | 0.574 | ||
Antithrombotic factor | aPTT, s | −0.669 | 15 |
HDL-C, mmol/L | −0.578 | ||
Glucose, mmol/L | 0.546 | ||
Prothrombotic factor | Gender | 0.635 | 12 |
PT, s | −0.536 | ||
TG, mmol/L | 0.522 |
Predictors | B (SE) | Wald Coefficient | OR (95% CI) | p |
---|---|---|---|---|
Proinflammatory factor | 0.995 (0.476) | 4.375 | 2.705 (1.065–6.875) | 0.036 |
Antithrombotic factor | −0.285 (0.506) | 0.319 | 0.752 (0.279–2.025) | 0.573 |
Prothrombotic factor | −0.751 (0.673) | 1.244 | 0.472 (0.126–1.766) | 0.265 |
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Vekic, J.; Klisic, A.; Kotur-Stevuljevic, J.; Milinkovic, N.; Gluscevic, S.; Ciftel, S.; Mercantepe, F. Sex-Specific Associations between Thyroid Status, Inflammation and Hemostasis Biomarkers in Patients with Subacute Thyroiditis. Biomedicines 2024, 12, 1862. https://doi.org/10.3390/biomedicines12081862
Vekic J, Klisic A, Kotur-Stevuljevic J, Milinkovic N, Gluscevic S, Ciftel S, Mercantepe F. Sex-Specific Associations between Thyroid Status, Inflammation and Hemostasis Biomarkers in Patients with Subacute Thyroiditis. Biomedicines. 2024; 12(8):1862. https://doi.org/10.3390/biomedicines12081862
Chicago/Turabian StyleVekic, Jelena, Aleksandra Klisic, Jelena Kotur-Stevuljevic, Neda Milinkovic, Sanja Gluscevic, Serpil Ciftel, and Filiz Mercantepe. 2024. "Sex-Specific Associations between Thyroid Status, Inflammation and Hemostasis Biomarkers in Patients with Subacute Thyroiditis" Biomedicines 12, no. 8: 1862. https://doi.org/10.3390/biomedicines12081862