Dysregulated Non-Coding RNA Expression in T Cells from Patients with Ankylosing Spondylitis Contributes to Its Immunopathogenesis
Abstract
:1. Introduction
2. Pathogenesis of AS
2.1. Genetic Inheritance
2.2. Environmental Factors
2.3. T Cells
2.3.1. CD4+ T Cells
2.3.2. Formation of Autoantibodies
2.3.3. CD8+ T Cells
3. NcRNAs
3.1. Overview of Abnormal Expression of ncRNA in Patients with AS
3.2. Abnormal Expression of ncRNAs in AS T Cells
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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ncRNAs | Validated Targets | Signaling Pathway | Function | Patient Number | Reference and Study Year |
---|---|---|---|---|---|
miR-16↑, miR-221↑and let-7i↑ | TLR-4 | LPS/TLR-4 | Enhanced IFN-γ expression | 22 | 2013 [58] |
let-7i | IGF-1R | mTOR/AKT | Induced autophagy | - | 2014 [61] |
miR-199a-5p↓ | Rheb | mTOR | Inhibited autophagy | 41 | 2017 [63] |
miR-10b-5p↑, miR-155-5p↑, and miR-210-3p↑ | MAP3K7 | MAPKs | Reduced Th17 differentiation and IL-17A production | 15 | 2017 [65] |
miR-16-1-3p↑, miR-28-5p↑, miR-199a-5p↑, and miR-126-3p↑ | - | - | - | 81 | 2019 [70] |
miR-130a-3p↓ | Homeobox B1 | Bcl-2/Bax pathway | Inhibited T-cell proliferation and induced T-cell apoptosis | 30 | 2019 [71] |
miR-29b-1-5p↑, miR-4449↑, miR-211-3p↑, miR-1914-3p↑, and miR-7114-5p↑ | Angiogenin | JAK/STAT pathway | Enhanced IFN-γ expression | 24 | 2018 [67] |
LOC100506014↓, LOC645166↓, lncEXD2-1↓, and LINC00282↓ | K63-linked polyubiquitin chains | JAK/STAT and NFkB pathway | Enhanced IL-23 expression | 30 | 2021 [72] |
* let-7b-5p↓ and let-7c-5p↓ miR-30d-5p↑, miR-93-5p↑, miR-23b-3p↑, miR-191–5p↑, miR-148b-3p↑,miR-146b-5p↑,miR-1260b↑, miR-130a-5p↑, miR-140-3p↑, miR-145-3p↑, miR-22-5p↑, miR-2277-5p↑, miR-27a-3p↑, miR-29a-3p↑, miR-30c-5p↑, miR-330-5p↑, miR-345-5p↑, miR-4717-3p↑, miR-500a-3p↑, miR-502-3p↑, miR-598-3p↑, miR-6810-3p↑ | - | Covalent chromatin modification, chromatin modifying enzymes, nuclear chromatin, chromatin DNA binding | Inhibited the proliferation of regulatory T cells | 17 | 2023 [75] |
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Yu, H.-C.; Wang, S.-T.; Lu, M.-C. Dysregulated Non-Coding RNA Expression in T Cells from Patients with Ankylosing Spondylitis Contributes to Its Immunopathogenesis. Biomedicines 2024, 12, 1873. https://doi.org/10.3390/biomedicines12081873
Yu H-C, Wang S-T, Lu M-C. Dysregulated Non-Coding RNA Expression in T Cells from Patients with Ankylosing Spondylitis Contributes to Its Immunopathogenesis. Biomedicines. 2024; 12(8):1873. https://doi.org/10.3390/biomedicines12081873
Chicago/Turabian StyleYu, Hui-Chun, Sz-Tsan Wang, and Ming-Chi Lu. 2024. "Dysregulated Non-Coding RNA Expression in T Cells from Patients with Ankylosing Spondylitis Contributes to Its Immunopathogenesis" Biomedicines 12, no. 8: 1873. https://doi.org/10.3390/biomedicines12081873