The Interplay between Mitochondrial Metabolism and Nasal Mucociliary Function as a Surrogate Method to Diagnose Thyroid Dysfunction: Insights from a Population-Based Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design, Participants, and Endpoints
2.2. Sample Size Calculation
2.3. Assessments
2.4. Ethical Issues
2.5. Statistical Analysis
3. Results
3.1. Descriptive Analysis
3.2. Correlation between Nasal Mucociliary Clearance Time and Thyroid Function Tests
3.3. Mucociliary Clearance over the TSH, T4, and Thyroid Function Groups
3.4. Diagnostic Value of Mucociliary Clearance Test in Differentiating Thyroid Function Disorders
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Patients (Total = 232) |
---|---|
Gender | |
Female, n (%) | 165 (71.1) |
Male, n (%) | 67 (28.9) |
Patient age at diagnosis (years) | |
10–30, n (%) | 59 (25.4) |
31–50, n (%) | 91 (39.2) |
51–70, n (%) | 66 (28.4) |
>70, n (%) | 16 (6.8) |
TSH (μIU/mL) | |
Mean/range/SD | 5.3/0.01–144.3/3.7 |
Low (<0.4) | 10 (4.3) |
Normal (0.4–6.1 or up to 10 in >50 years) | 201 (86.6) |
High (>6.1 or 10 in >50 years) | 21 (9.1) |
T4 (μg/dL) | |
Mean/range/SD | 7.9/1.4–29.5/2.8 |
Low (<4.5) | 7 (3.0) |
Normal (4.5–12.5) | 221 (95.3) |
High (>12.5) | 4 (1.7) |
Condition | |
Overt hypothyroidism | 7 (3.0) |
Subclinical hypothyroidism | 14 (6.0) |
Euthyroid | 201 (86.6) |
Subclinical hyperthyroidism | 6 (2.6) |
Overt hyperthyroidism | 4 (1.7) |
NMCT (min) | |
Right side | |
Mean | 15.3 |
Range/IQR | 4–28/11–19 |
SD | 5.10 |
Left side | |
Mean | 15.1 |
Range/IQR | 4–31/11–19 |
SD | 4.96 |
Average | |
Mean | 15.2 |
Range/IQR | 5–25/11.5–18.5 |
SD | 4.73 |
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Farhadi, M.; Ghanbari, H.; Salehi, A.; Ashique, S.; Taghizadeh-Hesary, F. The Interplay between Mitochondrial Metabolism and Nasal Mucociliary Function as a Surrogate Method to Diagnose Thyroid Dysfunction: Insights from a Population-Based Study. Biomedicines 2024, 12, 1897. https://doi.org/10.3390/biomedicines12081897
Farhadi M, Ghanbari H, Salehi A, Ashique S, Taghizadeh-Hesary F. The Interplay between Mitochondrial Metabolism and Nasal Mucociliary Function as a Surrogate Method to Diagnose Thyroid Dysfunction: Insights from a Population-Based Study. Biomedicines. 2024; 12(8):1897. https://doi.org/10.3390/biomedicines12081897
Chicago/Turabian StyleFarhadi, Mohammad, Hadi Ghanbari, Ali Salehi, Sumel Ashique, and Farzad Taghizadeh-Hesary. 2024. "The Interplay between Mitochondrial Metabolism and Nasal Mucociliary Function as a Surrogate Method to Diagnose Thyroid Dysfunction: Insights from a Population-Based Study" Biomedicines 12, no. 8: 1897. https://doi.org/10.3390/biomedicines12081897