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Volume 13
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10.3390/biomedicines13010047
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Review

Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors

by
Runhan Liu
1,2,3,
Jiaxin Zhou
4,5,
Xiaochen Chen
4,
Jie Zhang
4,5,
Qunzhi Chen
4,
Xiaoming Liu
1,2,* and
Kunhou Yao
1,2,*
1
Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China
2
School of Clinical Medicine, Henan University, Kaifeng 475004, China
3
School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia
4
School of Life Sciences, Henan University, Kaifeng 475004, China
5
School of Pharmacy, Henan University, Kaifeng 475004, China
*
Authors to whom correspondence should be addressed.
Biomedicines 2025, 13(1), 47; https://doi.org/10.3390/biomedicines13010047
Submission received: 7 November 2024 / Revised: 1 December 2024 / Accepted: 10 December 2024 / Published: 28 December 2024
(This article belongs to the Special Issue Pancreatic, Liver, Biliary Tract and Intestinal Diseases: Pathogenesis, Diagnostics and Therapy)
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Abstract

Gastrointestinal tumors present a significant challenge for precision medicine due to their complexity, necessitating the development of more specific diagnostic tools and therapeutic agents. Recent advances have positioned coding and non-coding RNAs as emerging biomarkers for these malignancies, detectable by liquid biopsies, and as innovative therapeutic agents. Many RNA-based therapeutics, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO), have entered clinical trials or are available on the market. This review provides a narrative examination of the diagnostic and therapeutic potential of RNA in gastrointestinal cancers, with an emphasis on its application in precision medicine. This review discusses the current challenges, such as drug resistance and tumor metastasis, and highlights how RNA molecules can be leveraged for targeted detection and treatment. Additionally, this review categorizes specific diagnostic biomarkers and RNA therapeutic targets based on tissue type, offering a comprehensive analysis of their role in advancing precision medicine for gastrointestinal tumors.
Keywords: gastrointestinal tumors; RNA; diagnosis; drug resistance; precision medicine gastrointestinal tumors; RNA; diagnosis; drug resistance; precision medicine

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MDPI and ACS Style

Liu, R.; Zhou, J.; Chen, X.; Zhang, J.; Chen, Q.; Liu, X.; Yao, K. Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors. Biomedicines 2025, 13, 47. https://doi.org/10.3390/biomedicines13010047

AMA Style

Liu R, Zhou J, Chen X, Zhang J, Chen Q, Liu X, Yao K. Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors. Biomedicines. 2025; 13(1):47. https://doi.org/10.3390/biomedicines13010047

Chicago/Turabian Style

Liu, Runhan, Jiaxin Zhou, Xiaochen Chen, Jie Zhang, Qunzhi Chen, Xiaoming Liu, and Kunhou Yao. 2025. "Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors" Biomedicines 13, no. 1: 47. https://doi.org/10.3390/biomedicines13010047

APA Style

Liu, R., Zhou, J., Chen, X., Zhang, J., Chen, Q., Liu, X., & Yao, K. (2025). Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors. Biomedicines, 13(1), 47. https://doi.org/10.3390/biomedicines13010047

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