3D Printing of Hydrogel Polysaccharides for Biomedical Applications: A Review

Additive manufacturing, also known as 3D printing, is becoming more and more popular because of its wide range of materials and flexibility in design. Layer by layer, 3D complex structures can be generated by the revolutionary computer-aided process known as 3D bioprinting. It is particularly crucial for youngsters and elderly patients and is a useful tool for tailored pharmaceutical therapy. A lot of research has been carried out recently on the use of polysaccharides as matrices for tissue engineering and medication delivery. Still, there is a great need to create affordable, sustainable bioink materials with high-quality mechanical, viscoelastic, and thermal properties as well as biocompatibility and biodegradability. The primary biological substances (biopolymers) chosen for the bioink formulation are proteins and polysaccharides, among the several resources utilized for the creation of such structures. These naturally occurring biomaterials give macromolecular structure and mechanical qualities (biomimicry), are generally compatible with tissues and cells (biocompatibility), and are harmonious with biological digesting processes (biodegradability). However, the primary difficulty with the cell-laden printing technique (bioprinting) is the rheological characteristics of these natural-based bioinks. Polysaccharides are widely used because they are abundant and reasonably priced natural polymers. Additionally, they serve as excipients in formulations for pharmaceuticals, nutraceuticals, and cosmetics. The remarkable benefits of biological polysaccharides—biocompatibility, biodegradability, safety, non-immunogenicity, and absence of secondary pollution—make them ideal 3D printing substrates. The purpose of this publication is to examine recent developments and challenges related to the 3D printing of stimuli-responsive polysaccharides for site-specific medication administration and tissue engineering.