Inflammatory Mediators and Pain in Endometriosis: A Systematic Review
Abstract
:1. Introduction
2. Methods
2.1. Data Sources and Search Strategy
2.2. Eligibility Criteria for Articles of Inclusion
2.3. Data Extraction
3. Results
3.1. Biological Role of Key Inflammatory Mediators
3.1.1. IL-1β Cytokine
3.1.2. TNF Cytokine
3.1.3. IL-15 Cytokine
3.1.4. IL-8 Cytokine
3.1.5. IL-6 Cytokine
3.1.6. IL-32, IL-33 Cytokines
3.1.7. S1P Cytokines
3.1.8. Chemokines
3.1.9. Neutrophil Extracellular Traps (NETs)
3.1.10. High-Mobility Group Box (HMGB)
3.2. Mediators of Inflammation and Their Expression in Endometriosis
3.3. Biomolecules That Stimulate Inflammation and Neuroangiogenesis in Endometriosis
4. Discussion
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Cytokines-Chemokines | Expression in Endometriosis |
---|---|
IL-1β | Overexpression in endometrium and the peritoneal fluid [35,36]-no significantly different in the peritoneal fluid in advance stage [37] |
IL-2 | Lower expression in serum [38] |
IL-6 | Higher expression the peritoneal fluid and serum-dependence on the severity [36,39,40,41] |
IL-7 | Higher expression in eutopic DIE [42] |
IL-8 | Overexpression in the endometrium [35,40] |
IL-10 | Higher in the peritoneal fluid and serum/anti-inflammatory properties [36,38,43] |
IL-15 | Higher in ectopic DIE [42] |
IL-17A | Lower in serum [38]/IL-17AF higher in the peritoneal fluid and serum [36] |
IL-32 | High concentration in the peritoneal fluid-depend on the severity [37] |
IL-33 | Higher levels in ectopic lesions [44] |
IL-37 | Higher expression in serum—anti-inflammatory role [38,43,45,46] |
TNF-α | Overexpression in endometrium [35] |
CXCR4 (CXCR4-CXCL12 activation) | Depends on the type of lesion [47] |
CXCR7 (CXCL12-CXCR7 activation) | Upregulation in ectopic glands-depending on cells type (epithelial > stromal) [48] |
CX3CL1/CX3CR1 | Upregulation CX3CL1 on macrophages and CX3CR1 on myelin sheath of sciatic nerve fibers [49] |
CXCL9 | Decrease levels in serum [50] |
NET | Increased in plasma [51] |
TGF-β | Increased in the peritoneal fluid and serum [36] |
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Machairiotis, N.; Vasilakaki, S.; Thomakos, N. Inflammatory Mediators and Pain in Endometriosis: A Systematic Review. Biomedicines 2021, 9, 54. https://doi.org/10.3390/biomedicines9010054
Machairiotis N, Vasilakaki S, Thomakos N. Inflammatory Mediators and Pain in Endometriosis: A Systematic Review. Biomedicines. 2021; 9(1):54. https://doi.org/10.3390/biomedicines9010054
Chicago/Turabian StyleMachairiotis, Nikolaos, Sofia Vasilakaki, and Nikolaos Thomakos. 2021. "Inflammatory Mediators and Pain in Endometriosis: A Systematic Review" Biomedicines 9, no. 1: 54. https://doi.org/10.3390/biomedicines9010054