Controlled Synthesis of Up-Conversion NaYF4:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis of Np-UCs
2.2. Synthesis of 7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid (CF)
2.3. Tert-butyl 4-(1-cyclopropyl-3-((((diphenylmethylene)amino)oxy)carbonyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazine-1-carboxylate (CF-OE)
2.4. Characterization Methods
2.5. Photophysical Measurements
2.6. Light-Induced Drug Delivered Experiments
3. Results and Discussion
3.1. Optimization of the Synthesis of NaYF4:Yb/Tm UC Materials
3.2. Light-Driven Drug Delivery
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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UCi(i) | pH | Time (h) | Thermal Treatment (400 °C) | Proportion of β (%) |
---|---|---|---|---|
1 | 5 | 12 | YES | 56.9 |
2 | 5 | 24 | YES | 100 |
3 | 5 | 24 | NO | 100 |
4 | 6 | 24 | NO | 100 |
5 | 7 | 24 | NO | 100 |
6 | 8 | 24 | NO | 100 |
7 | 10 | 24 | NO | 100 |
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Moyano Rodríguez, E.; Gomez-Mendoza, M.; Pérez-Ruiz, R.; Peñín, B.; Sampedro, D.; Caamaño, A.; de la Peña O’Shea, V.A. Controlled Synthesis of Up-Conversion NaYF4:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy. Biomedicines 2021, 9, 1953. https://doi.org/10.3390/biomedicines9121953
Moyano Rodríguez E, Gomez-Mendoza M, Pérez-Ruiz R, Peñín B, Sampedro D, Caamaño A, de la Peña O’Shea VA. Controlled Synthesis of Up-Conversion NaYF4:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy. Biomedicines. 2021; 9(12):1953. https://doi.org/10.3390/biomedicines9121953
Chicago/Turabian StyleMoyano Rodríguez, Edelweiss, Miguel Gomez-Mendoza, Raúl Pérez-Ruiz, Beatriz Peñín, Diego Sampedro, Antonio Caamaño, and Víctor A. de la Peña O’Shea. 2021. "Controlled Synthesis of Up-Conversion NaYF4:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy" Biomedicines 9, no. 12: 1953. https://doi.org/10.3390/biomedicines9121953