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Biomedicines
Volume 9
Issue 5
10.3390/biomedicines9050557
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Review

Immunosurveillance of Cancer and Viral Infections with Regard to Alterations of Human NK Cells Originating from Lifestyle and Aging

by
Xuewen Deng
1,*,
Hiroshi Terunuma
1,2 and
Mie Nieda
1
1
Biotherapy Institute of Japan, Inc., 2-4-8 Edagawa, Koto-ku, Tokyo 135-0051, Japan
2
N2 Clinic Yotsuya, 5F 2-6 Samon-cho, Shinjuku-ku, Tokyo 160-0017, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2021, 9(5), 557; https://doi.org/10.3390/biomedicines9050557
Submission received: 22 March 2021 / Revised: 29 April 2021 / Accepted: 14 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Recent Therapeutic Advances in Natural Killer Cells)
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Abstract

Natural killer (NK) cells are cytotoxic immune cells with an innate capacity for eliminating cancer cells and virus- infected cells. NK cells are critical effector cells in the immunosurveillance of cancer and viral infections. Patients with low NK cell activity or NK cell deficiencies are predisposed to increased risks of cancer and severe viral infections. However, functional alterations of human NK cells are associated with lifestyles and aging. Personal lifestyles, such as cigarette smoking, alcohol consumption, stress, obesity, and aging are correlated with NK cell dysfunction, whereas adequate sleep, moderate exercise, forest bathing, and listening to music are associated with functional healthy NK cells. Therefore, adherence to a healthy lifestyle is essential and will be favorable for immunosurveillance of cancer and viral infections with healthy NK cells.
Keywords: NK cell; immunosurveillance; lifestyle; aging; cancer; viral infection NK cell; immunosurveillance; lifestyle; aging; cancer; viral infection

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MDPI and ACS Style

Deng, X.; Terunuma, H.; Nieda, M. Immunosurveillance of Cancer and Viral Infections with Regard to Alterations of Human NK Cells Originating from Lifestyle and Aging. Biomedicines 2021, 9, 557. https://doi.org/10.3390/biomedicines9050557

AMA Style

Deng X, Terunuma H, Nieda M. Immunosurveillance of Cancer and Viral Infections with Regard to Alterations of Human NK Cells Originating from Lifestyle and Aging. Biomedicines. 2021; 9(5):557. https://doi.org/10.3390/biomedicines9050557

Chicago/Turabian Style

Deng, Xuewen, Hiroshi Terunuma, and Mie Nieda. 2021. "Immunosurveillance of Cancer and Viral Infections with Regard to Alterations of Human NK Cells Originating from Lifestyle and Aging" Biomedicines 9, no. 5: 557. https://doi.org/10.3390/biomedicines9050557

APA Style

Deng, X., Terunuma, H., & Nieda, M. (2021). Immunosurveillance of Cancer and Viral Infections with Regard to Alterations of Human NK Cells Originating from Lifestyle and Aging. Biomedicines, 9(5), 557. https://doi.org/10.3390/biomedicines9050557

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